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A Human Serum-Based Enzyme-Free Continuous Glucose Monitoring Technique Using a Needle-Type Bio-Layer Interference Sensor

The incidence of diabetes is continually increasing, and by 2030, it is expected to have increased by 69% and 20% in underdeveloped and developed countries, respectively. Therefore, glucose sensors are likely to remain in high demand in medical device markets. For the current study, we developed a n...

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Detalles Bibliográficos
Autores principales: Seo, Dongmin, Paek, Sung-Ho, Oh, Sangwoo, Seo, Sungkyu, Paek, Se-Hwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087370/
https://www.ncbi.nlm.nih.gov/pubmed/27669267
http://dx.doi.org/10.3390/s16101581
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author Seo, Dongmin
Paek, Sung-Ho
Oh, Sangwoo
Seo, Sungkyu
Paek, Se-Hwan
author_facet Seo, Dongmin
Paek, Sung-Ho
Oh, Sangwoo
Seo, Sungkyu
Paek, Se-Hwan
author_sort Seo, Dongmin
collection PubMed
description The incidence of diabetes is continually increasing, and by 2030, it is expected to have increased by 69% and 20% in underdeveloped and developed countries, respectively. Therefore, glucose sensors are likely to remain in high demand in medical device markets. For the current study, we developed a needle-type bio-layer interference (BLI) sensor that can continuously monitor glucose levels. Using dialysis procedures, we were able to obtain hypoglycemic samples from commercial human serum. These dialysis-derived samples, alongside samples of normal human serum were used to evaluate the utility of the sensor for the detection of the clinical interest range of glucose concentrations (70–200 mg/dL), revealing high system performance for a wide glycemic state range (45–500 mg/dL). Reversibility and reproducibility were also tested over a range of time spans. Combined with existing BLI system technology, this sensor holds great promise for use as a wearable online continuous glucose monitoring system for patients in a hospital setting.
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spelling pubmed-50873702016-11-07 A Human Serum-Based Enzyme-Free Continuous Glucose Monitoring Technique Using a Needle-Type Bio-Layer Interference Sensor Seo, Dongmin Paek, Sung-Ho Oh, Sangwoo Seo, Sungkyu Paek, Se-Hwan Sensors (Basel) Communication The incidence of diabetes is continually increasing, and by 2030, it is expected to have increased by 69% and 20% in underdeveloped and developed countries, respectively. Therefore, glucose sensors are likely to remain in high demand in medical device markets. For the current study, we developed a needle-type bio-layer interference (BLI) sensor that can continuously monitor glucose levels. Using dialysis procedures, we were able to obtain hypoglycemic samples from commercial human serum. These dialysis-derived samples, alongside samples of normal human serum were used to evaluate the utility of the sensor for the detection of the clinical interest range of glucose concentrations (70–200 mg/dL), revealing high system performance for a wide glycemic state range (45–500 mg/dL). Reversibility and reproducibility were also tested over a range of time spans. Combined with existing BLI system technology, this sensor holds great promise for use as a wearable online continuous glucose monitoring system for patients in a hospital setting. MDPI 2016-09-24 /pmc/articles/PMC5087370/ /pubmed/27669267 http://dx.doi.org/10.3390/s16101581 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Seo, Dongmin
Paek, Sung-Ho
Oh, Sangwoo
Seo, Sungkyu
Paek, Se-Hwan
A Human Serum-Based Enzyme-Free Continuous Glucose Monitoring Technique Using a Needle-Type Bio-Layer Interference Sensor
title A Human Serum-Based Enzyme-Free Continuous Glucose Monitoring Technique Using a Needle-Type Bio-Layer Interference Sensor
title_full A Human Serum-Based Enzyme-Free Continuous Glucose Monitoring Technique Using a Needle-Type Bio-Layer Interference Sensor
title_fullStr A Human Serum-Based Enzyme-Free Continuous Glucose Monitoring Technique Using a Needle-Type Bio-Layer Interference Sensor
title_full_unstemmed A Human Serum-Based Enzyme-Free Continuous Glucose Monitoring Technique Using a Needle-Type Bio-Layer Interference Sensor
title_short A Human Serum-Based Enzyme-Free Continuous Glucose Monitoring Technique Using a Needle-Type Bio-Layer Interference Sensor
title_sort human serum-based enzyme-free continuous glucose monitoring technique using a needle-type bio-layer interference sensor
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087370/
https://www.ncbi.nlm.nih.gov/pubmed/27669267
http://dx.doi.org/10.3390/s16101581
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