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Quasi-3D Modeling and Efficient Simulation of Laminar Flows in Microfluidic Devices
A quasi-3D model has been developed to simulate the flow in planar microfluidic systems with low Reynolds numbers. The model was developed by decomposing the flow profile along the height of a microfluidic system into a Fourier series. It was validated against the analytical solution for flow in a s...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087427/ https://www.ncbi.nlm.nih.gov/pubmed/27706104 http://dx.doi.org/10.3390/s16101639 |
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author | Islam, Md. Zahurul Tsui, Ying Yin |
author_facet | Islam, Md. Zahurul Tsui, Ying Yin |
author_sort | Islam, Md. Zahurul |
collection | PubMed |
description | A quasi-3D model has been developed to simulate the flow in planar microfluidic systems with low Reynolds numbers. The model was developed by decomposing the flow profile along the height of a microfluidic system into a Fourier series. It was validated against the analytical solution for flow in a straight rectangular channel and the full 3D numerical COMSOL Navier-Stokes solver for flow in a T-channel. Comparable accuracy to the full 3D numerical solution was achieved by using only three Fourier terms with a significant decrease in computation time. The quasi-3D model was used to model flows in a micro-flow cytometer chip on a desktop computer and good agreement between the simulation and the experimental results was found. |
format | Online Article Text |
id | pubmed-5087427 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-50874272016-11-07 Quasi-3D Modeling and Efficient Simulation of Laminar Flows in Microfluidic Devices Islam, Md. Zahurul Tsui, Ying Yin Sensors (Basel) Article A quasi-3D model has been developed to simulate the flow in planar microfluidic systems with low Reynolds numbers. The model was developed by decomposing the flow profile along the height of a microfluidic system into a Fourier series. It was validated against the analytical solution for flow in a straight rectangular channel and the full 3D numerical COMSOL Navier-Stokes solver for flow in a T-channel. Comparable accuracy to the full 3D numerical solution was achieved by using only three Fourier terms with a significant decrease in computation time. The quasi-3D model was used to model flows in a micro-flow cytometer chip on a desktop computer and good agreement between the simulation and the experimental results was found. MDPI 2016-10-03 /pmc/articles/PMC5087427/ /pubmed/27706104 http://dx.doi.org/10.3390/s16101639 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Islam, Md. Zahurul Tsui, Ying Yin Quasi-3D Modeling and Efficient Simulation of Laminar Flows in Microfluidic Devices |
title | Quasi-3D Modeling and Efficient Simulation of Laminar Flows in Microfluidic Devices |
title_full | Quasi-3D Modeling and Efficient Simulation of Laminar Flows in Microfluidic Devices |
title_fullStr | Quasi-3D Modeling and Efficient Simulation of Laminar Flows in Microfluidic Devices |
title_full_unstemmed | Quasi-3D Modeling and Efficient Simulation of Laminar Flows in Microfluidic Devices |
title_short | Quasi-3D Modeling and Efficient Simulation of Laminar Flows in Microfluidic Devices |
title_sort | quasi-3d modeling and efficient simulation of laminar flows in microfluidic devices |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087427/ https://www.ncbi.nlm.nih.gov/pubmed/27706104 http://dx.doi.org/10.3390/s16101639 |
work_keys_str_mv | AT islammdzahurul quasi3dmodelingandefficientsimulationoflaminarflowsinmicrofluidicdevices AT tsuiyingyin quasi3dmodelingandefficientsimulationoflaminarflowsinmicrofluidicdevices |