Mutant IP(3) receptors attenuate store-operated Ca(2+) entry by destabilizing STIM–Orai interactions in Drosophila neurons

Store-operated Ca(2+) entry (SOCE) occurs when loss of Ca(2+) from the endoplasmic reticulum (ER) stimulates the Ca(2+) sensor, STIM, to cluster and activate the plasma membrane Ca(2+) channel Orai (encoded by Olf186-F in flies). Inositol 1,4,5-trisphosphate receptors (IP(3)Rs, which are encoded by...

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Detalles Bibliográficos
Autores principales: Chakraborty, Sumita, Deb, Bipan K., Chorna, Tetyana, Konieczny, Vera, Taylor, Colin W., Hasan, Gaiti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087660/
https://www.ncbi.nlm.nih.gov/pubmed/27591258
http://dx.doi.org/10.1242/jcs.191585

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087660/
https://www.ncbi.nlm.nih.gov/pubmed/27591258
http://dx.doi.org/10.1242/jcs.191585

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