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Polo-like kinase phosphorylation determines Caenorhabditis elegans centrosome size and density by biasing SPD-5 toward an assembly-competent conformation
Centrosomes are major microtubule-organizing centers composed of centrioles surrounded by an extensive proteinacious layer called the pericentriolar material (PCM). In Caenorhabditis elegans embryos, the mitotic PCM expands by Polo-like kinase 1 (PLK-1) phosphorylation-accelerated assembly of SPD-5...
Autores principales: | Wueseke, Oliver, Zwicker, David, Schwager, Anne, Wong, Yao Liang, Oegema, Karen, Jülicher, Frank, Hyman, Anthony A., Woodruff, Jeffrey B. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Company of Biologists Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087692/ https://www.ncbi.nlm.nih.gov/pubmed/27591191 http://dx.doi.org/10.1242/bio.020990 |
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