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Halting of Caspase Activity Protects Tau from MC1-Conformational Change and Aggregation
Intracellular neurofibrillary tangles (NFTs) are the hallmark of Alzheimer’s disease and other tauopathies in which tau, a microtubule-associated protein, loses its ability to stabilize microtubules. Several post-translational modifications including phosphorylation and truncation increase tau’s pro...
Autores principales: | Mead, Emma, Kestoras, Dimitra, Gibson, Yolanda, Hamilton, Lucy, Goodson, Ross, Jones, Sophie, Eversden, Sarah, Davies, Peter, O’Neill, Michael, Hutton, Michael, Szekeres, Philip, Wolak, Joanna |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
IOS Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088409/ https://www.ncbi.nlm.nih.gov/pubmed/27589517 http://dx.doi.org/10.3233/JAD-150960 |
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