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Changes of macular pigment optical density in elderly eyes: a longitudinal analysis from the MARS study
BACKGROUND: Macular pigment (MP) has been related to the occurrence of age related macular degeneration (AMD). We investigated prospectively in eyes of elderly individuals how magnitude and spatial distribution of MP had changed after 4 years. METHODS: The study included 380 eyes from 237 participan...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088485/ https://www.ncbi.nlm.nih.gov/pubmed/27847632 http://dx.doi.org/10.1186/s40942-016-0039-6 |
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author | Meyer zu Westrup, Verena Dietzel, Martha Zeimer, Meike Pauleikhoff, Daniel Hense, Hans-Werner |
author_facet | Meyer zu Westrup, Verena Dietzel, Martha Zeimer, Meike Pauleikhoff, Daniel Hense, Hans-Werner |
author_sort | Meyer zu Westrup, Verena |
collection | PubMed |
description | BACKGROUND: Macular pigment (MP) has been related to the occurrence of age related macular degeneration (AMD). We investigated prospectively in eyes of elderly individuals how magnitude and spatial distribution of MP had changed after 4 years. METHODS: The study included 380 eyes from 237 participants of the Münster Ageing and Retina Study cohort which were free of advanced stages of AMD. MP optical density (MPOD) was measured in density units (D.U.) at eccentricities of 0.25°, 0.5°, 1.0° and 2.0° from the fovea using dual-wavelength autofluorescence; ring-like MP distributions were identified from MP density profiles. Changes were assessed with mixed linear models. RESULTS: The study participants’ mean age at baseline was 70.5 years. Early AMD was present in 150 study eyes (39.5 %) and a ring-like distribution of MPOD was found in 87 study eyes (22.9 %). After a median follow-up time of 3.96 years, the MPOD averaged over all eyes was slightly raised at the central fovea (from 0.658 to 0.670 D.U. (relative change +1.8 %), p = 0.08) and most markedly at 2.0° (from 0.157 to 0.172 D.U. (+9.5 %), p < 0.001). Multivariate analyses, adjusting for sex, body mass and carotenoid supplement intake, revealed that MPOD increments, at any distance from the fovea, were slightly less pronounced in older eyes. Serum concentrations of lutein at follow-up, presumably reflecting recent intake of antioxidant supplements, raised MPOD levels significantly at 1.0° and 2.0° (both p < 0.01) but not in the central fovea. Early AMD at baseline and ring-like MPOD distribution did not significantly impact on MPOD changes over time. A ring-like spatial distribution of MPOD persisted in over 80 % of the affected eyes. CONCLUSIONS: Overall, the magnitude and spatial arrangement of MPOD was remarkably stable over time in elderly eyes. Significant MPOD rises in perifoveal regions probably indicate effects of lutein containing supplements. The persistence of ring-like MPOD distributions over time seems to suggest their determination by anatomical structures. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s40942-016-0039-6) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-5088485 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-50884852016-11-15 Changes of macular pigment optical density in elderly eyes: a longitudinal analysis from the MARS study Meyer zu Westrup, Verena Dietzel, Martha Zeimer, Meike Pauleikhoff, Daniel Hense, Hans-Werner Int J Retina Vitreous Original Article BACKGROUND: Macular pigment (MP) has been related to the occurrence of age related macular degeneration (AMD). We investigated prospectively in eyes of elderly individuals how magnitude and spatial distribution of MP had changed after 4 years. METHODS: The study included 380 eyes from 237 participants of the Münster Ageing and Retina Study cohort which were free of advanced stages of AMD. MP optical density (MPOD) was measured in density units (D.U.) at eccentricities of 0.25°, 0.5°, 1.0° and 2.0° from the fovea using dual-wavelength autofluorescence; ring-like MP distributions were identified from MP density profiles. Changes were assessed with mixed linear models. RESULTS: The study participants’ mean age at baseline was 70.5 years. Early AMD was present in 150 study eyes (39.5 %) and a ring-like distribution of MPOD was found in 87 study eyes (22.9 %). After a median follow-up time of 3.96 years, the MPOD averaged over all eyes was slightly raised at the central fovea (from 0.658 to 0.670 D.U. (relative change +1.8 %), p = 0.08) and most markedly at 2.0° (from 0.157 to 0.172 D.U. (+9.5 %), p < 0.001). Multivariate analyses, adjusting for sex, body mass and carotenoid supplement intake, revealed that MPOD increments, at any distance from the fovea, were slightly less pronounced in older eyes. Serum concentrations of lutein at follow-up, presumably reflecting recent intake of antioxidant supplements, raised MPOD levels significantly at 1.0° and 2.0° (both p < 0.01) but not in the central fovea. Early AMD at baseline and ring-like MPOD distribution did not significantly impact on MPOD changes over time. A ring-like spatial distribution of MPOD persisted in over 80 % of the affected eyes. CONCLUSIONS: Overall, the magnitude and spatial arrangement of MPOD was remarkably stable over time in elderly eyes. Significant MPOD rises in perifoveal regions probably indicate effects of lutein containing supplements. The persistence of ring-like MPOD distributions over time seems to suggest their determination by anatomical structures. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s40942-016-0039-6) contains supplementary material, which is available to authorized users. BioMed Central 2016-06-01 /pmc/articles/PMC5088485/ /pubmed/27847632 http://dx.doi.org/10.1186/s40942-016-0039-6 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Original Article Meyer zu Westrup, Verena Dietzel, Martha Zeimer, Meike Pauleikhoff, Daniel Hense, Hans-Werner Changes of macular pigment optical density in elderly eyes: a longitudinal analysis from the MARS study |
title | Changes of macular pigment optical density in elderly eyes: a longitudinal analysis from the MARS study |
title_full | Changes of macular pigment optical density in elderly eyes: a longitudinal analysis from the MARS study |
title_fullStr | Changes of macular pigment optical density in elderly eyes: a longitudinal analysis from the MARS study |
title_full_unstemmed | Changes of macular pigment optical density in elderly eyes: a longitudinal analysis from the MARS study |
title_short | Changes of macular pigment optical density in elderly eyes: a longitudinal analysis from the MARS study |
title_sort | changes of macular pigment optical density in elderly eyes: a longitudinal analysis from the mars study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088485/ https://www.ncbi.nlm.nih.gov/pubmed/27847632 http://dx.doi.org/10.1186/s40942-016-0039-6 |
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