Cargando…

Umbilical Cord Blood Transplantation-associated Nephrotic Syndrome Successfully Treated by Low-density Lipoprotein Apheresis

The development of nephrotic syndrome (NS) after umbilical cord transplantation (UBT) has been reported in only four cases to date. We herein report the case of a 50-year-old woman who developed NS 94 days after UBT. She fell into oliguria and required dialysis. A kidney biopsy revealed focal and se...

Descripción completa

Detalles Bibliográficos
Autores principales: Sugawara, Yuka, Honda, Kenjiro, Katagiri, Daisuke, Nakamura, Motonobu, Kawakami, Takahisa, Nasu, Ryo, Hayashi, Akimasa, Shintani, Yukako, Tojo, Akihiro, Noiri, Eisei, Kurokawa, Mineo, Fukayama, Masashi, Nangaku, Masaomi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088545/
https://www.ncbi.nlm.nih.gov/pubmed/27725544
_version_ 1782464115583746048
author Sugawara, Yuka
Honda, Kenjiro
Katagiri, Daisuke
Nakamura, Motonobu
Kawakami, Takahisa
Nasu, Ryo
Hayashi, Akimasa
Shintani, Yukako
Tojo, Akihiro
Noiri, Eisei
Kurokawa, Mineo
Fukayama, Masashi
Nangaku, Masaomi
author_facet Sugawara, Yuka
Honda, Kenjiro
Katagiri, Daisuke
Nakamura, Motonobu
Kawakami, Takahisa
Nasu, Ryo
Hayashi, Akimasa
Shintani, Yukako
Tojo, Akihiro
Noiri, Eisei
Kurokawa, Mineo
Fukayama, Masashi
Nangaku, Masaomi
author_sort Sugawara, Yuka
collection PubMed
description The development of nephrotic syndrome (NS) after umbilical cord transplantation (UBT) has been reported in only four cases to date. We herein report the case of a 50-year-old woman who developed NS 94 days after UBT. She fell into oliguria and required dialysis. A kidney biopsy revealed focal and segmental glomerulosclerosis. Although glucocorticoid monotherapy did not improve her condition, the addition of low-density lipoprotein (LDL) apheresis resulted in remission of NS, a drastic improvement in her renal function, and withdrawal from dialysis. To the best of our knowledge, this is the first report of UBT-associated NS treated with LDL apheresis.
format Online
Article
Text
id pubmed-5088545
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher The Japanese Society of Internal Medicine
record_format MEDLINE/PubMed
spelling pubmed-50885452016-11-07 Umbilical Cord Blood Transplantation-associated Nephrotic Syndrome Successfully Treated by Low-density Lipoprotein Apheresis Sugawara, Yuka Honda, Kenjiro Katagiri, Daisuke Nakamura, Motonobu Kawakami, Takahisa Nasu, Ryo Hayashi, Akimasa Shintani, Yukako Tojo, Akihiro Noiri, Eisei Kurokawa, Mineo Fukayama, Masashi Nangaku, Masaomi Intern Med Case Report The development of nephrotic syndrome (NS) after umbilical cord transplantation (UBT) has been reported in only four cases to date. We herein report the case of a 50-year-old woman who developed NS 94 days after UBT. She fell into oliguria and required dialysis. A kidney biopsy revealed focal and segmental glomerulosclerosis. Although glucocorticoid monotherapy did not improve her condition, the addition of low-density lipoprotein (LDL) apheresis resulted in remission of NS, a drastic improvement in her renal function, and withdrawal from dialysis. To the best of our knowledge, this is the first report of UBT-associated NS treated with LDL apheresis. The Japanese Society of Internal Medicine 2016-10-01 /pmc/articles/PMC5088545/ /pubmed/27725544 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Sugawara, Yuka
Honda, Kenjiro
Katagiri, Daisuke
Nakamura, Motonobu
Kawakami, Takahisa
Nasu, Ryo
Hayashi, Akimasa
Shintani, Yukako
Tojo, Akihiro
Noiri, Eisei
Kurokawa, Mineo
Fukayama, Masashi
Nangaku, Masaomi
Umbilical Cord Blood Transplantation-associated Nephrotic Syndrome Successfully Treated by Low-density Lipoprotein Apheresis
title Umbilical Cord Blood Transplantation-associated Nephrotic Syndrome Successfully Treated by Low-density Lipoprotein Apheresis
title_full Umbilical Cord Blood Transplantation-associated Nephrotic Syndrome Successfully Treated by Low-density Lipoprotein Apheresis
title_fullStr Umbilical Cord Blood Transplantation-associated Nephrotic Syndrome Successfully Treated by Low-density Lipoprotein Apheresis
title_full_unstemmed Umbilical Cord Blood Transplantation-associated Nephrotic Syndrome Successfully Treated by Low-density Lipoprotein Apheresis
title_short Umbilical Cord Blood Transplantation-associated Nephrotic Syndrome Successfully Treated by Low-density Lipoprotein Apheresis
title_sort umbilical cord blood transplantation-associated nephrotic syndrome successfully treated by low-density lipoprotein apheresis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088545/
https://www.ncbi.nlm.nih.gov/pubmed/27725544
work_keys_str_mv AT sugawarayuka umbilicalcordbloodtransplantationassociatednephroticsyndromesuccessfullytreatedbylowdensitylipoproteinapheresis
AT hondakenjiro umbilicalcordbloodtransplantationassociatednephroticsyndromesuccessfullytreatedbylowdensitylipoproteinapheresis
AT katagiridaisuke umbilicalcordbloodtransplantationassociatednephroticsyndromesuccessfullytreatedbylowdensitylipoproteinapheresis
AT nakamuramotonobu umbilicalcordbloodtransplantationassociatednephroticsyndromesuccessfullytreatedbylowdensitylipoproteinapheresis
AT kawakamitakahisa umbilicalcordbloodtransplantationassociatednephroticsyndromesuccessfullytreatedbylowdensitylipoproteinapheresis
AT nasuryo umbilicalcordbloodtransplantationassociatednephroticsyndromesuccessfullytreatedbylowdensitylipoproteinapheresis
AT hayashiakimasa umbilicalcordbloodtransplantationassociatednephroticsyndromesuccessfullytreatedbylowdensitylipoproteinapheresis
AT shintaniyukako umbilicalcordbloodtransplantationassociatednephroticsyndromesuccessfullytreatedbylowdensitylipoproteinapheresis
AT tojoakihiro umbilicalcordbloodtransplantationassociatednephroticsyndromesuccessfullytreatedbylowdensitylipoproteinapheresis
AT noirieisei umbilicalcordbloodtransplantationassociatednephroticsyndromesuccessfullytreatedbylowdensitylipoproteinapheresis
AT kurokawamineo umbilicalcordbloodtransplantationassociatednephroticsyndromesuccessfullytreatedbylowdensitylipoproteinapheresis
AT fukayamamasashi umbilicalcordbloodtransplantationassociatednephroticsyndromesuccessfullytreatedbylowdensitylipoproteinapheresis
AT nangakumasaomi umbilicalcordbloodtransplantationassociatednephroticsyndromesuccessfullytreatedbylowdensitylipoproteinapheresis