Drug-induced Pneumonitis Following the Administration of TAS-102

A 59-year-old woman, diagnosed with advanced rectal cancer, presented with a low-grade fever and dyspnea on exertion after the 2nd cycle of TAS-102. TAS-102 has promising efficacy in patients with metastatic colorectal cancer. A CT scan revealed mosaic patterns with bilateral ground-glass opacities....

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Detalles Bibliográficos
Autores principales: Hasegawa, Yoshikazu, Ota, Takayo, Tsukuda, Hiroshi, Suzumura, Tomohiro, Fukuoka, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088549/
https://www.ncbi.nlm.nih.gov/pubmed/27725548
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author Hasegawa, Yoshikazu
Ota, Takayo
Tsukuda, Hiroshi
Suzumura, Tomohiro
Fukuoka, Masahiro
author_facet Hasegawa, Yoshikazu
Ota, Takayo
Tsukuda, Hiroshi
Suzumura, Tomohiro
Fukuoka, Masahiro
author_sort Hasegawa, Yoshikazu
collection PubMed
description A 59-year-old woman, diagnosed with advanced rectal cancer, presented with a low-grade fever and dyspnea on exertion after the 2nd cycle of TAS-102. TAS-102 has promising efficacy in patients with metastatic colorectal cancer. A CT scan revealed mosaic patterns with bilateral ground-glass opacities. The drug lymphocyte stimulation test for TAS-102 was strongly positive and serum β-D glucan level was elevated. The clinical course was compatible with TAS-102-induced pneumonitis combined with pneumocystis pneumonia (PCP). We herein report a rare case of drug-induced pneumonitis in a patient receiving TAS-102 in combination with PCP.
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spelling pubmed-50885492016-11-07 Drug-induced Pneumonitis Following the Administration of TAS-102 Hasegawa, Yoshikazu Ota, Takayo Tsukuda, Hiroshi Suzumura, Tomohiro Fukuoka, Masahiro Intern Med Case Report A 59-year-old woman, diagnosed with advanced rectal cancer, presented with a low-grade fever and dyspnea on exertion after the 2nd cycle of TAS-102. TAS-102 has promising efficacy in patients with metastatic colorectal cancer. A CT scan revealed mosaic patterns with bilateral ground-glass opacities. The drug lymphocyte stimulation test for TAS-102 was strongly positive and serum β-D glucan level was elevated. The clinical course was compatible with TAS-102-induced pneumonitis combined with pneumocystis pneumonia (PCP). We herein report a rare case of drug-induced pneumonitis in a patient receiving TAS-102 in combination with PCP. The Japanese Society of Internal Medicine 2016-10-01 /pmc/articles/PMC5088549/ /pubmed/27725548 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Hasegawa, Yoshikazu
Ota, Takayo
Tsukuda, Hiroshi
Suzumura, Tomohiro
Fukuoka, Masahiro
Drug-induced Pneumonitis Following the Administration of TAS-102
title Drug-induced Pneumonitis Following the Administration of TAS-102
title_full Drug-induced Pneumonitis Following the Administration of TAS-102
title_fullStr Drug-induced Pneumonitis Following the Administration of TAS-102
title_full_unstemmed Drug-induced Pneumonitis Following the Administration of TAS-102
title_short Drug-induced Pneumonitis Following the Administration of TAS-102
title_sort drug-induced pneumonitis following the administration of tas-102
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088549/
https://www.ncbi.nlm.nih.gov/pubmed/27725548
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