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Synthetic lethality between PAXX and XLF in mammalian development

PAXX was identified recently as a novel nonhomologous end-joining DNA repair factor in human cells. To characterize its physiological roles, we generated Paxx-deficient mice. Like Xlf(−/−) mice, Paxx(−/−) mice are viable, grow normally, and are fertile but show mild radiosensitivity. Strikingly, whi...

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Detalles Bibliográficos
Autores principales:	Balmus, Gabriel, Barros, Ana C., Wijnhoven, Paul W.G., Lescale, Chloé, Hasse, Hélène Lenden, Boroviak, Katharina, le Sage, Carlos, Doe, Brendan, Speak, Anneliese O., Galli, Antonella, Jacobsen, Matt, Deriano, Ludovic, Adams, David J., Blackford, Andrew N., Jackson, Stephen P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2016
Materias:	Research Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088564/ https://www.ncbi.nlm.nih.gov/pubmed/27798842 http://dx.doi.org/10.1101/gad.290510.116

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