Condensin II mutation causes T-cell lymphoma through tissue-specific genome instability

Chromosomal instability is a hallmark of cancer, but mitotic regulators are rarely mutated in tumors. Mutations in the condensin complexes, which restructure chromosomes to facilitate segregation during mitosis, are significantly enriched in cancer genomes, but experimental evidence implicating cond...

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Detalles Bibliográficos
Autores principales: Woodward, Jessica, Taylor, Gillian C., Soares, Dinesh C., Boyle, Shelagh, Sie, Daoud, Read, David, Chathoth, Keerthi, Vukovic, Milica, Tarrats, Nuria, Jamieson, David, Campbell, Kirsteen J., Blyth, Karen, Acosta, Juan Carlos, Ylstra, Bauke, Arends, Mark J., Kranc, Kamil R., Jackson, Andrew P., Bickmore, Wendy A., Wood, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088566/
https://www.ncbi.nlm.nih.gov/pubmed/27737961
http://dx.doi.org/10.1101/gad.284562.116

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