SWI/SNF regulates a transcriptional program that induces senescence to prevent liver cancer

Oncogene-induced senescence (OIS) is a potent tumor suppressor mechanism. To identify senescence regulators relevant to cancer, we screened an shRNA library targeting genes deleted in hepatocellular carcinoma (HCC). Here, we describe how knockdown of the SWI/SNF component ARID1B prevents OIS and coo...

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Detalles Bibliográficos
Autores principales: Tordella, Luca, Khan, Sadaf, Hohmeyer, Anja, Banito, Ana, Klotz, Sabrina, Raguz, Selina, Martin, Nadine, Dhamarlingam, Gopuraja, Carroll, Thomas, González Meljem, José Mario, Deswal, Sumit, Martínez-Barbera, Juan Pedro, García-Escudero, Ramón, Zuber, Johannes, Zender, Lars, Gil, Jesús
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088567/
https://www.ncbi.nlm.nih.gov/pubmed/27737960
http://dx.doi.org/10.1101/gad.286112.116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088567/
https://www.ncbi.nlm.nih.gov/pubmed/27737960
http://dx.doi.org/10.1101/gad.286112.116

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