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Loss of Uhrf1 in neural stem cells leads to activation of retroviral elements and delayed neurodegeneration
In order to understand whether early epigenetic mechanisms instruct the long-term behavior of neural stem cells (NSCs) and their progeny, we examined Uhrf1 (ubiquitin-like PHD ring finger-1; also known as Np95), as it is highly expressed in NSCs of the developing brain and rapidly down-regulated upo...
Autores principales: | Ramesh, Vidya, Bayam, Efil, Cernilogar, Filippo M., Bonapace, Ian M., Schulze, Markus, Riemenschneider, Markus J., Schotta, Gunnar, Götz, Magdalena |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088568/ https://www.ncbi.nlm.nih.gov/pubmed/27798843 http://dx.doi.org/10.1101/gad.284992.116 |
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