Genome-wide repression of eRNA and target gene loci by the ETV6-RUNX1 fusion in acute leukemia

Approximately 20%–25% of childhood acute lymphoblastic leukemias carry the ETV6-RUNX1 (E/R) fusion gene, a fusion of two central hematopoietic transcription factors, ETV6 (TEL) and RUNX1 (AML1). Despite its prevalence, the exact genomic targets of E/R have remained elusive. We evaluated gene loci an...

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Detalles Bibliográficos
Autores principales: Teppo, Susanna, Laukkanen, Saara, Liuksiala, Thomas, Nordlund, Jessica, Oittinen, Mikko, Teittinen, Kaisa, Grönroos, Toni, St-Onge, Pascal, Sinnett, Daniel, Syvänen, Ann-Christine, Nykter, Matti, Viiri, Keijo, Heinäniemi, Merja, Lohi, Olli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088590/
https://www.ncbi.nlm.nih.gov/pubmed/27620872
http://dx.doi.org/10.1101/gr.193649.115

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