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Complete Spectrum of CRISPR/Cas9-induced Mutations on HBV cccDNA

Hepatitis B virus (HBV) causes chronic infections that cannot yet be cured. The virus persists in infected hepatocytes, because covalently closed circular DNA (cccDNA), the template for the transcription of viral RNAs, is stable in nondividing cells. Antiviral therapies with nucleoside analogues inh...

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Detalles Bibliográficos
Autores principales:	Seeger, Christoph, Sohn, Ji A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088770/ https://www.ncbi.nlm.nih.gov/pubmed/27203444 http://dx.doi.org/10.1038/mt.2016.94

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