Recent advances in Entamoeba biology: RNA interference, drug discovery, and gut microbiome

In recent years, substantial progress has been made in understanding the molecular and cell biology of the human parasite Entamoeba histolytica, an important pathogen with significant global impact. This review outlines some recent advances in the Entamoeba field in the last five years, focusing on...

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Detalles Bibliográficos
Autores principales: Morgado, Pedro, Manna, Dipak, Singh, Upinder
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089142/
https://www.ncbi.nlm.nih.gov/pubmed/27853522
http://dx.doi.org/10.12688/f1000research.9241.1
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author Morgado, Pedro
Manna, Dipak
Singh, Upinder
author_facet Morgado, Pedro
Manna, Dipak
Singh, Upinder
author_sort Morgado, Pedro
collection PubMed
description In recent years, substantial progress has been made in understanding the molecular and cell biology of the human parasite Entamoeba histolytica, an important pathogen with significant global impact. This review outlines some recent advances in the Entamoeba field in the last five years, focusing on areas that have not recently been discussed in detail: (i) molecular mechanisms regulating parasite gene expression, (ii) new efforts at drug discovery using high-throughput drug screens, and (iii) the effect of gut microbiota on amoebiasis.
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spelling pubmed-50891422016-11-15 Recent advances in Entamoeba biology: RNA interference, drug discovery, and gut microbiome Morgado, Pedro Manna, Dipak Singh, Upinder F1000Res Review In recent years, substantial progress has been made in understanding the molecular and cell biology of the human parasite Entamoeba histolytica, an important pathogen with significant global impact. This review outlines some recent advances in the Entamoeba field in the last five years, focusing on areas that have not recently been discussed in detail: (i) molecular mechanisms regulating parasite gene expression, (ii) new efforts at drug discovery using high-throughput drug screens, and (iii) the effect of gut microbiota on amoebiasis. F1000Research 2016-10-26 /pmc/articles/PMC5089142/ /pubmed/27853522 http://dx.doi.org/10.12688/f1000research.9241.1 Text en Copyright: © 2016 Morgado P et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Morgado, Pedro
Manna, Dipak
Singh, Upinder
Recent advances in Entamoeba biology: RNA interference, drug discovery, and gut microbiome
title Recent advances in Entamoeba biology: RNA interference, drug discovery, and gut microbiome
title_full Recent advances in Entamoeba biology: RNA interference, drug discovery, and gut microbiome
title_fullStr Recent advances in Entamoeba biology: RNA interference, drug discovery, and gut microbiome
title_full_unstemmed Recent advances in Entamoeba biology: RNA interference, drug discovery, and gut microbiome
title_short Recent advances in Entamoeba biology: RNA interference, drug discovery, and gut microbiome
title_sort recent advances in entamoeba biology: rna interference, drug discovery, and gut microbiome
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089142/
https://www.ncbi.nlm.nih.gov/pubmed/27853522
http://dx.doi.org/10.12688/f1000research.9241.1
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