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Glycyrrhizin Reduces HMGB1 and Bacterial Load in Pseudomonas aeruginosa Keratitis

PURPOSE: High mobility group box 1 (HMGB1) contributes to poor disease outcome in Pseudomonas aeruginosa keratitis. This study tests the prophylactic effect of treatment with HMGB1 inhibitors, glycyrrhizin (GLY) and its derivative, carbenoxolone (CBX), for Pseudomonas keratitis. METHODS: We treated...

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Detalles Bibliográficos
Autores principales:	Ekanayaka, Sandamali A., McClellan, Sharon A., Barrett, Ronald P., Kharotia, Shikhil, Hazlett, Linda D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2016
Materias:	Immunology and Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089214/ https://www.ncbi.nlm.nih.gov/pubmed/27792814 http://dx.doi.org/10.1167/iovs.16-20103

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