Non-clinical studies required for new drug development - Part I: early in silico and in vitro studies, new target discovery and validation, proof of principles and robustness of animal studies

This review presents a historical overview of drug discovery and the non-clinical stages of the drug development process, from initial target identification and validation, through in silico assays and high throughput screening (HTS), identification of leader molecules and their optimization, the se...

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Detalles Bibliográficos
Autores principales: Andrade, E.L., Bento, A.F., Cavalli, J., Oliveira, S.K., Freitas, C.S., Marcon, R., Schwanke, R.C., Siqueira, J.M., Calixto, J.B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Brasileira de Divulgação Científica 2016
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089235/
https://www.ncbi.nlm.nih.gov/pubmed/27783811
http://dx.doi.org/10.1590/1414-431X20165644

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