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Patella bone density is lower in knee osteoarthritis patients experiencing moderate-to-severe pain at rest

OBJECTIVE: To determine differences in patellar subchondral bone mineral density (BMD) between knee osteoarthritis (OA) patients with differing levels of pain at rest. METHODS: The preoperative knee of 41 total knee replacement (TKR) patients was scanned using QCT and scored for pain using Western O...

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Autores principales: Burnett, W., Kontulainen, S., McLennan, C., Hazel, D., Talmo, C., Hunter, D., Wilson, D., Johnston, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Society of Musculoskeletal and Neuronal Interactions 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089452/
https://www.ncbi.nlm.nih.gov/pubmed/26944821
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author Burnett, W.
Kontulainen, S.
McLennan, C.
Hazel, D.
Talmo, C.
Hunter, D.
Wilson, D.
Johnston, J.
author_facet Burnett, W.
Kontulainen, S.
McLennan, C.
Hazel, D.
Talmo, C.
Hunter, D.
Wilson, D.
Johnston, J.
author_sort Burnett, W.
collection PubMed
description OBJECTIVE: To determine differences in patellar subchondral bone mineral density (BMD) between knee osteoarthritis (OA) patients with differing levels of pain at rest. METHODS: The preoperative knee of 41 total knee replacement (TKR) patients was scanned using QCT and scored for pain using Western Ontario McMasters Osteoarthritis Index (WOMAC). ‘Pain at rest’ was defined as average pain while lying/sitting and nocturnal pain. Participants were divided into groups: ‘mild-to-no pain at rest’ and ‘moderate-to-severe pain at rest’. We used a depth-specific CT-based mapping technique to measure patellar subchondral BMD at depths of 0-2.5 mm, 2.5-5 mm, and 5-7.5 mm from the subchondral surface. Mean lateral and medial facet BMD were compared between groups using MANCOVA. RESULTS: Mean adjusted BMD was lower in participants with ‘moderate-to-severe pain at rest’ over the total lateral facet at depths of 0-2.5 mm (10% lower, p=0.041), 2.5-5 mm (20% lower, p=0.017), and 5-7.5 mm (25% lower, p=0.004), and over the total medial facet at 2.5-5 mm (22% lower, p=0.033) and 5-7.5 mm (28% lower, p=0.016). CONCLUSIONS: In OA patients with ‘moderate-to-severe pain at rest’, depth-specific density measures demonstrated up to 28% lower lateral and medial subchondral BMD. Patients with high levels of pain at rest may have reduced amounts of native bone prior to TKR.
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spelling pubmed-50894522016-11-21 Patella bone density is lower in knee osteoarthritis patients experiencing moderate-to-severe pain at rest Burnett, W. Kontulainen, S. McLennan, C. Hazel, D. Talmo, C. Hunter, D. Wilson, D. Johnston, J. J Musculoskelet Neuronal Interact Original Article OBJECTIVE: To determine differences in patellar subchondral bone mineral density (BMD) between knee osteoarthritis (OA) patients with differing levels of pain at rest. METHODS: The preoperative knee of 41 total knee replacement (TKR) patients was scanned using QCT and scored for pain using Western Ontario McMasters Osteoarthritis Index (WOMAC). ‘Pain at rest’ was defined as average pain while lying/sitting and nocturnal pain. Participants were divided into groups: ‘mild-to-no pain at rest’ and ‘moderate-to-severe pain at rest’. We used a depth-specific CT-based mapping technique to measure patellar subchondral BMD at depths of 0-2.5 mm, 2.5-5 mm, and 5-7.5 mm from the subchondral surface. Mean lateral and medial facet BMD were compared between groups using MANCOVA. RESULTS: Mean adjusted BMD was lower in participants with ‘moderate-to-severe pain at rest’ over the total lateral facet at depths of 0-2.5 mm (10% lower, p=0.041), 2.5-5 mm (20% lower, p=0.017), and 5-7.5 mm (25% lower, p=0.004), and over the total medial facet at 2.5-5 mm (22% lower, p=0.033) and 5-7.5 mm (28% lower, p=0.016). CONCLUSIONS: In OA patients with ‘moderate-to-severe pain at rest’, depth-specific density measures demonstrated up to 28% lower lateral and medial subchondral BMD. Patients with high levels of pain at rest may have reduced amounts of native bone prior to TKR. International Society of Musculoskeletal and Neuronal Interactions 2016-03 /pmc/articles/PMC5089452/ /pubmed/26944821 Text en Copyright: © Journal of Musculoskeletal and Neuronal Interactions http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Burnett, W.
Kontulainen, S.
McLennan, C.
Hazel, D.
Talmo, C.
Hunter, D.
Wilson, D.
Johnston, J.
Patella bone density is lower in knee osteoarthritis patients experiencing moderate-to-severe pain at rest
title Patella bone density is lower in knee osteoarthritis patients experiencing moderate-to-severe pain at rest
title_full Patella bone density is lower in knee osteoarthritis patients experiencing moderate-to-severe pain at rest
title_fullStr Patella bone density is lower in knee osteoarthritis patients experiencing moderate-to-severe pain at rest
title_full_unstemmed Patella bone density is lower in knee osteoarthritis patients experiencing moderate-to-severe pain at rest
title_short Patella bone density is lower in knee osteoarthritis patients experiencing moderate-to-severe pain at rest
title_sort patella bone density is lower in knee osteoarthritis patients experiencing moderate-to-severe pain at rest
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089452/
https://www.ncbi.nlm.nih.gov/pubmed/26944821
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