Clozapine N-Oxide Administration Produces Behavioral Effects in Long–Evans Rats: Implications for Designing DREADD Experiments

Clozapine N-oxide (CNO) is a ligand for a powerful chemogenetic system that can selectively inhibit or activate neurons; the so-called Designer Receptors Exclusively Activated by Designer Drugs (DREADD) system. This system consists of synthetic G-protein-coupled receptors, which are not believed to...

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Detalles Bibliográficos
Autores principales: MacLaren, Duncan A. A., Browne, Richard W., Shaw, Jessica K., Krishnan Radhakrishnan, Sandhya, Khare, Prachi, España, Rodrigo A., Clark, Stewart D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2016
Materias:
New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089539/
https://www.ncbi.nlm.nih.gov/pubmed/27822508
http://dx.doi.org/10.1523/ENEURO.0219-16.2016

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