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Expression and polymorphism (rs4880) of mitochondrial superoxide dismutase (SOD2) and asparaginase induced hepatotoxicity in adult patients with acute lymphoblastic leukemia

Asparaginase, which depletes asparagine and glutamine, activates amino acid stress response. Oxidative stress mediated by excessive reactive oxygen species (ROS) causes enhanced mitochondrial permeabilization and subsequent cell apoptosis and is considered a plausible mechanism for drug-induced hepa...

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Detalles Bibliográficos
Autores principales:	Alachkar, Houda, Fulton, Noreen, Sanford, Ben, Malnassy, Greg, Mutonga, Martin, Larson, Richard A., Bloomfield, Clara D., Marcucci, Guido, Nakamura, Yusuke, Stock, Wendy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089920/ https://www.ncbi.nlm.nih.gov/pubmed/27019981 http://dx.doi.org/10.1038/tpj.2016.7

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