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Independent activation of distinct pores in dimeric TMEM16A channels

The TMEM16 family encompasses Ca(2+)-activated Cl(−) channels (CaCCs) and lipid scramblases. These proteins are formed by two identical subunits, as confirmed by the recently solved crystal structure of a TMEM16 lipid scramblase. However, the high-resolution structure did not provide definitive info...

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Detalles Bibliográficos
Autores principales: Jeng, Grace, Aggarwal, Muskaan, Yu, Wei-Ping, Chen, Tsung-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089935/
https://www.ncbi.nlm.nih.gov/pubmed/27799319
http://dx.doi.org/10.1085/jgp.201611651