Cargando…

Reducing Peripheral Inflammation with Infliximab Reduces Neuroinflammation and Improves Cognition in Rats with Hepatic Encephalopathy

Inflammation contributes to cognitive impairment in patients with hepatic encephalopathy (HE). However, the process by which peripheral inflammation results in cognitive impairment remains unclear. In animal models, neuroinflammation and altered neurotransmission mediate cognitive impairment. Taking...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dadsetan, Sherry, Balzano, Tiziano, Forteza, Jerónimo, Cabrera-Pastor, Andrea, Taoro-Gonzalez, Lucas, Hernandez-Rabaza, Vicente, Gil-Perotín, Sara, Cubas-Núñez, Laura, García-Verdugo, José-Manuel, Agusti, Ana, Llansola, Marta, Felipo, Vicente
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2016
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089983/ https://www.ncbi.nlm.nih.gov/pubmed/27853420 http://dx.doi.org/10.3389/fnmol.2016.00106

Ejemplares similares

Infliximab reduces peripheral inflammation, neuroinflammation, and extracellular GABA in the cerebellum and improves learning and motor coordination in rats with hepatic encephalopathy
por: Dadsetan, Sherry, et al.
Publicado: (2016)

Sildenafil reduces neuroinflammation and restores spatial learning in rats with hepatic encephalopathy: underlying mechanisms
por: Hernandez-Rabaza, Vicente, et al.
Publicado: (2015)

Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia
por: Hernandez-Rabaza, Vicente, et al.
Publicado: (2016)

Sustained hyperammonemia induces TNF-a IN Purkinje neurons by activating the TNFR1-NF-κB pathway
por: Balzano, Tiziano, et al.
Publicado: (2020)

Hyperammonemia induces glial activation, neuroinflammation and alters neurotransmitter receptors in hippocampus, impairing spatial learning: reversal by sulforaphane
por: Hernández-Rabaza, Vicente, et al.
Publicado: (2016)

The Dual Role of the GABA(A) Receptor in Peripheral Inflammation and Neuroinflammation: A Study in Hyperammonemic Rats
por: Malaguarnera, Michele, et al.
Publicado: (2021)

Bicuculline Reduces Neuroinflammation in Hippocampus and Improves Spatial Learning and Anxiety in Hyperammonemic Rats. Role of Glutamate Receptors
por: Malaguarnera, Michele, et al.
Publicado: (2019)

Rifaximin Improves Spatial Learning and Memory Impairment in Rats with Liver Damage-Associated Neuroinflammation
por: Leone, Paola, et al.
Publicado: (2022)

Extracellular cGMP Modulates Learning Biphasically by Modulating Glycine Receptors, CaMKII and Glutamate-Nitric Oxide-cGMP Pathway
por: Cabrera-Pastor, Andrea, et al.
Publicado: (2016)

Bacteroides uniformis CECT 7771 Modulates the Brain Reward Response to Reduce Binge Eating and Anxiety-Like Behavior in Rat
por: Agustí, Ana, et al.
Publicado: (2021)

Extracellular Cyclic GMP Modulates Membrane Expression of The GluA1 and GluA2 Subunits of AMPA Receptor in Cerebellum: Molecular Mechanisms Involved
por: Cabrera-Pastor, Andrea, et al.
Publicado: (2017)

The Cerebellum of Patients with Steatohepatitis Shows Lymphocyte Infiltration, Microglial Activation and Loss of Purkinje and Granular Neurons
por: Balzano, Tiziano, et al.
Publicado: (2018)

Potential Neuroprotective Role of Sugammadex: A Clinical Study on Cognitive Function Assessment in an Enhanced Recovery After Cardiac Surgery Approach and an Experimental Study
por: Muedra, Vicente, et al.
Publicado: (2022)

GR3027 antagonizes GABA(A) receptor-potentiating neurosteroids and restores spatial learning and motor coordination in rats with chronic hyperammonemia and hepatic encephalopathy
por: Johansson, Maja, et al.
Publicado: (2015)

Blocking glycine receptors reduces neuroinflammation and restores neurotransmission in cerebellum through ADAM17-TNFR1-NF-κβ pathway
por: Arenas, Yaiza M., et al.
Publicado: (2020)

Hyperammonemia alters membrane expression of GluA1 and GluA2 subunits of AMPA receptors in hippocampus by enhancing activation of the IL-1 receptor: underlying mechanisms
por: Taoro-Gonzalez, Lucas, et al.
Publicado: (2018)

Rifaximin Prevents T-Lymphocytes and Macrophages Infiltration in Cerebellum and Restores Motor Incoordination in Rats with Mild Liver Damage
por: Balzano, Tiziano, et al.
Publicado: (2021)

The expression levels of prolyl oligopeptidase responds not only to neuroinflammation but also to systemic inflammation upon liver failure in rat models and cirrhotic patients
por: Tenorio-Laranga, Jofre, et al.
Publicado: (2015)

Extracellular vesicles from mesenchymal stem cells reduce neuroinflammation in hippocampus and restore cognitive function in hyperammonemic rats
por: Izquierdo-Altarejos, Paula, et al.
Publicado: (2023)

Enhanced BDNF and TrkB Activation Enhance GABA Neurotransmission in Cerebellum in Hyperammonemia
por: Arenas, Yaiza M., et al.
Publicado: (2022)

Extracellular Vesicles from Hyperammonemic Rats Induce Neuroinflammation and Motor Incoordination in Control Rats
por: Izquierdo-Altarejos, Paula, et al.
Publicado: (2020)

Golexanolone, a GABA(A) receptor modulating steroid antagonist, restores motor coordination and cognitive function in hyperammonemic rats by dual effects on peripheral inflammation and neuroinflammation
por: Mincheva, Gergana, et al.
Publicado: (2022)

Reduced resting state connectivity and gray matter volume correlate with cognitive impairment in minimal hepatic encephalopathy
por: García-García, Raquel, et al.
Publicado: (2017)

Extracellular Vesicles From Hyperammonemic Rats Induce Neuroinflammation in Cerebellum of Normal Rats: Role of Increased TNFα Content
por: Izquierdo-Altarejos, Paula, et al.
Publicado: (2022)

Active Clinical Trials in Hepatic Encephalopathy: Something Old, Something New and Something Borrowed
por: Balzano, Tiziano
Publicado: (2023)

Inhibition of γ-Secretase Leads to an Increase in Presenilin-1
por: Sogorb-Esteve, Aitana, et al.
Publicado: (2017)

(−)-Epicatechin Reduces Neuroinflammation, Protects Mitochondria Function, and Prevents Cognitive Impairment in Sepsis-Associated Encephalopathy
por: Ling, Jianmin, et al.
Publicado: (2022)

Pharmacological manipulation of cyclic GMP levels in brain restores learning ability in animal models of hepatic encephalopathy: therapeutic implications
por: Rodrigo, Regina, et al.
Publicado: (2006)

In situ RT-PCR Optimized for Electron Microscopy Allows Description of Subcellular Morphology of Target mRNA-Expressing Cells in the Brain
por: Cubas-Nuñez, Laura, et al.
Publicado: (2017)

Plasma Extracellular Vesicles Play a Role in Immune System Modulation in Minimal Hepatic Encephalopathy
por: Gallego, Juan José, et al.
Publicado: (2022)

Posterior Reversible Encephalopathy Syndrome in a Patient With Crohn’s Disease on Infliximab
por: Chow, Stephen, et al.
Publicado: (2016)

cGMP modulates stem cells differentiation to neurons in brain in vivo pathological implications
por: Gómez-Pinedo, Ulises, et al.
Publicado: (2011)

Cocaine and MDMA Induce Cellular and Molecular Changes in Adult Neurogenic Systems: Functional Implications
por: Capilla-Gonzalez, Vivian, et al.
Publicado: (2011)

Infliximab and Etanercept Are Equally Effective in Reducing Enterocyte APOPTOSIS in Experimental Colitis
por: Fries, Walter, et al.
Publicado: (2008)

Infliximab reduces Zaprinast-induced retinal degeneration in cultures of porcine retina
por: Martínez-Fernández de la Cámara, Cristina, et al.
Publicado: (2014)

Methotrexate Reduced TNF Bioactivity in Rheumatoid Arthritis Patients Treated with Infliximab
por: Dénarié, Delphine, et al.
Publicado: (2017)

Multi-omic analysis unveils biological pathways in peripheral immune system associated to minimal hepatic encephalopathy appearance in cirrhotic patients
por: Rubio, Teresa, et al.
Publicado: (2021)

Long-term potentiation in hippocampus involves sequential activation of soluble guanylate cyclase, cGMP-dependent protein kinase and cGMP-degrading phosphodiesterase, alterations in hyperammonemia
por: Monfort, Pilar, et al.
Publicado: (2005)

Minimal hepatic encephalopathy is associated to alterations in eye movements
por: Casanova-Ferrer, Franc, et al.
Publicado: (2022)

Progesterone, Lipoic Acid, and Sulforaphane as Promising Antioxidants for Retinal Diseases: A Review
por: Hernández-Rabaza, Vicente, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_5gb4qqi2hm7nua9kk4ajkk7488