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Study of the Serum Copper Levels in Patients with Major Depressive Disorder

Copper may be involved in the pathophysiology of depression. Clinical data on this issue are very limited and not conclusive. The purpose of the study was to determine the copper concentration in the serum of patients with major depressive disorder and to discuss its potential clinical usefulness as...

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Autores principales: Styczeń, Krzysztof, Sowa-Kućma, Magdalena, Siwek, Marcin, Dudek, Dominika, Reczyński, Witold, Misztak, Paulina, Szewczyk, Bernadeta, Topór-Mądry, Roman, Opoka, Włodzimierz, Nowak, Gabriel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090008/
https://www.ncbi.nlm.nih.gov/pubmed/27147437
http://dx.doi.org/10.1007/s12011-016-0720-5
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author Styczeń, Krzysztof
Sowa-Kućma, Magdalena
Siwek, Marcin
Dudek, Dominika
Reczyński, Witold
Misztak, Paulina
Szewczyk, Bernadeta
Topór-Mądry, Roman
Opoka, Włodzimierz
Nowak, Gabriel
author_facet Styczeń, Krzysztof
Sowa-Kućma, Magdalena
Siwek, Marcin
Dudek, Dominika
Reczyński, Witold
Misztak, Paulina
Szewczyk, Bernadeta
Topór-Mądry, Roman
Opoka, Włodzimierz
Nowak, Gabriel
author_sort Styczeń, Krzysztof
collection PubMed
description Copper may be involved in the pathophysiology of depression. Clinical data on this issue are very limited and not conclusive. The purpose of the study was to determine the copper concentration in the serum of patients with major depressive disorder and to discuss its potential clinical usefulness as a biomarker of the disease. A case–control clinical study included 69 patients with current depressive episode, 45 patients in remission and 50 healthy volunteers. Cu concentration was measured by electrothermal atomic absorption spectrometry (ETAAS). The mean serum copper level in depressed patients was slightly lower (by 11 %; not statistically significant) than in the control group. Furthermore, there was no significant difference in Cu(2+) concentration between depressive episode and remission, nor between remission and control group. In the remission group were observed significant correlations between copper levels and the average number of relapses over the past years or time of remission. There was no correlation between serum copper and severity of depression, as measured by HDRS and MADRS. The obtained results showed no significant differences between the copper concentration in the blood serum of patients (both with current depressive episode and in remission) and healthy volunteers, as well as the lack of correlations between the copper level in the active stage of the disease and clinical features of the population. Our study is the first conducted on such a large population of patients, so the results may be particularly important and reliable source of knowledge about the potential role of copper in depression.
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spelling pubmed-50900082016-11-17 Study of the Serum Copper Levels in Patients with Major Depressive Disorder Styczeń, Krzysztof Sowa-Kućma, Magdalena Siwek, Marcin Dudek, Dominika Reczyński, Witold Misztak, Paulina Szewczyk, Bernadeta Topór-Mądry, Roman Opoka, Włodzimierz Nowak, Gabriel Biol Trace Elem Res Article Copper may be involved in the pathophysiology of depression. Clinical data on this issue are very limited and not conclusive. The purpose of the study was to determine the copper concentration in the serum of patients with major depressive disorder and to discuss its potential clinical usefulness as a biomarker of the disease. A case–control clinical study included 69 patients with current depressive episode, 45 patients in remission and 50 healthy volunteers. Cu concentration was measured by electrothermal atomic absorption spectrometry (ETAAS). The mean serum copper level in depressed patients was slightly lower (by 11 %; not statistically significant) than in the control group. Furthermore, there was no significant difference in Cu(2+) concentration between depressive episode and remission, nor between remission and control group. In the remission group were observed significant correlations between copper levels and the average number of relapses over the past years or time of remission. There was no correlation between serum copper and severity of depression, as measured by HDRS and MADRS. The obtained results showed no significant differences between the copper concentration in the blood serum of patients (both with current depressive episode and in remission) and healthy volunteers, as well as the lack of correlations between the copper level in the active stage of the disease and clinical features of the population. Our study is the first conducted on such a large population of patients, so the results may be particularly important and reliable source of knowledge about the potential role of copper in depression. Springer US 2016-05-05 2016 /pmc/articles/PMC5090008/ /pubmed/27147437 http://dx.doi.org/10.1007/s12011-016-0720-5 Text en © The Author(s) 2016 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Article
Styczeń, Krzysztof
Sowa-Kućma, Magdalena
Siwek, Marcin
Dudek, Dominika
Reczyński, Witold
Misztak, Paulina
Szewczyk, Bernadeta
Topór-Mądry, Roman
Opoka, Włodzimierz
Nowak, Gabriel
Study of the Serum Copper Levels in Patients with Major Depressive Disorder
title Study of the Serum Copper Levels in Patients with Major Depressive Disorder
title_full Study of the Serum Copper Levels in Patients with Major Depressive Disorder
title_fullStr Study of the Serum Copper Levels in Patients with Major Depressive Disorder
title_full_unstemmed Study of the Serum Copper Levels in Patients with Major Depressive Disorder
title_short Study of the Serum Copper Levels in Patients with Major Depressive Disorder
title_sort study of the serum copper levels in patients with major depressive disorder
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090008/
https://www.ncbi.nlm.nih.gov/pubmed/27147437
http://dx.doi.org/10.1007/s12011-016-0720-5
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