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Rostral Agranular Insular Cortex Lesion with Motor Cortex Stimulation Enhances Pain Modulation Effect on Neuropathic Pain Model

It is well known that the insular cortex is involved in the processing of painful input. The aim of this study was to evaluate the pain modulation role of the insular cortex during motor cortex stimulation (MCS). After inducing neuropathic pain (NP) rat models by the spared nerve injury method, we m...

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Autores principales: Jung, Hyun Ho, Shin, Jaewoo, Kim, Jinhyung, Ahn, Seung-Hee, Lee, Sung Eun, Koh, Chin Su, Cho, Jae Sung, Kong, Chanho, Shin, Hyung-Cheul, Kim, Sung June, Chang, Jin Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090091/
https://www.ncbi.nlm.nih.gov/pubmed/27833762
http://dx.doi.org/10.1155/2016/3898924
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author Jung, Hyun Ho
Shin, Jaewoo
Kim, Jinhyung
Ahn, Seung-Hee
Lee, Sung Eun
Koh, Chin Su
Cho, Jae Sung
Kong, Chanho
Shin, Hyung-Cheul
Kim, Sung June
Chang, Jin Woo
author_facet Jung, Hyun Ho
Shin, Jaewoo
Kim, Jinhyung
Ahn, Seung-Hee
Lee, Sung Eun
Koh, Chin Su
Cho, Jae Sung
Kong, Chanho
Shin, Hyung-Cheul
Kim, Sung June
Chang, Jin Woo
author_sort Jung, Hyun Ho
collection PubMed
description It is well known that the insular cortex is involved in the processing of painful input. The aim of this study was to evaluate the pain modulation role of the insular cortex during motor cortex stimulation (MCS). After inducing neuropathic pain (NP) rat models by the spared nerve injury method, we made a lesion on the rostral agranular insular cortex (RAIC) unilaterally and compared behaviorally determined pain threshold and latency in 2 groups: Group A (NP + MCS; n = 7) and Group B (NP + RAIC lesion + MCS; n = 7). Also, we simultaneously recorded neuronal activity (NP; n = 9) in the thalamus of the ventral posterolateral nucleus and RAIC to evaluate electrophysiological changes from MCS. The pain threshold and tolerance latency increased in Group A with “MCS on” and in Group B with or without “MCS on.” Moreover, its increase in Group B with “MCS on” was more than that of Group B without MCS or of Group A, suggesting that MCS and RAIC lesioning are involved in pain modulation. Compared with the “MCS off” condition, the “MCS on” induced significant threshold changes in an electrophysiological study. Our data suggest that the RAIC has its own pain modulation effect, which is influenced by MCS.
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spelling pubmed-50900912016-11-10 Rostral Agranular Insular Cortex Lesion with Motor Cortex Stimulation Enhances Pain Modulation Effect on Neuropathic Pain Model Jung, Hyun Ho Shin, Jaewoo Kim, Jinhyung Ahn, Seung-Hee Lee, Sung Eun Koh, Chin Su Cho, Jae Sung Kong, Chanho Shin, Hyung-Cheul Kim, Sung June Chang, Jin Woo Neural Plast Research Article It is well known that the insular cortex is involved in the processing of painful input. The aim of this study was to evaluate the pain modulation role of the insular cortex during motor cortex stimulation (MCS). After inducing neuropathic pain (NP) rat models by the spared nerve injury method, we made a lesion on the rostral agranular insular cortex (RAIC) unilaterally and compared behaviorally determined pain threshold and latency in 2 groups: Group A (NP + MCS; n = 7) and Group B (NP + RAIC lesion + MCS; n = 7). Also, we simultaneously recorded neuronal activity (NP; n = 9) in the thalamus of the ventral posterolateral nucleus and RAIC to evaluate electrophysiological changes from MCS. The pain threshold and tolerance latency increased in Group A with “MCS on” and in Group B with or without “MCS on.” Moreover, its increase in Group B with “MCS on” was more than that of Group B without MCS or of Group A, suggesting that MCS and RAIC lesioning are involved in pain modulation. Compared with the “MCS off” condition, the “MCS on” induced significant threshold changes in an electrophysiological study. Our data suggest that the RAIC has its own pain modulation effect, which is influenced by MCS. Hindawi Publishing Corporation 2016 2016-10-19 /pmc/articles/PMC5090091/ /pubmed/27833762 http://dx.doi.org/10.1155/2016/3898924 Text en Copyright © 2016 Hyun Ho Jung et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Jung, Hyun Ho
Shin, Jaewoo
Kim, Jinhyung
Ahn, Seung-Hee
Lee, Sung Eun
Koh, Chin Su
Cho, Jae Sung
Kong, Chanho
Shin, Hyung-Cheul
Kim, Sung June
Chang, Jin Woo
Rostral Agranular Insular Cortex Lesion with Motor Cortex Stimulation Enhances Pain Modulation Effect on Neuropathic Pain Model
title Rostral Agranular Insular Cortex Lesion with Motor Cortex Stimulation Enhances Pain Modulation Effect on Neuropathic Pain Model
title_full Rostral Agranular Insular Cortex Lesion with Motor Cortex Stimulation Enhances Pain Modulation Effect on Neuropathic Pain Model
title_fullStr Rostral Agranular Insular Cortex Lesion with Motor Cortex Stimulation Enhances Pain Modulation Effect on Neuropathic Pain Model
title_full_unstemmed Rostral Agranular Insular Cortex Lesion with Motor Cortex Stimulation Enhances Pain Modulation Effect on Neuropathic Pain Model
title_short Rostral Agranular Insular Cortex Lesion with Motor Cortex Stimulation Enhances Pain Modulation Effect on Neuropathic Pain Model
title_sort rostral agranular insular cortex lesion with motor cortex stimulation enhances pain modulation effect on neuropathic pain model
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090091/
https://www.ncbi.nlm.nih.gov/pubmed/27833762
http://dx.doi.org/10.1155/2016/3898924
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