TDP‐43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons

Nuclear clearance of TDP‐43 into cytoplasmic aggregates is a key driver of neurodegeneration in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), but the mechanisms are unclear. Here, we show that TDP‐43 knockdown specifically reduces the number and motility of RAB11‐...

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Detalles Bibliográficos
Autores principales: Schwenk, Benjamin M, Hartmann, Hannelore, Serdaroglu, Alperen, Schludi, Martin H, Hornburg, Daniel, Meissner, Felix, Orozco, Denise, Colombo, Alessio, Tahirovic, Sabina, Michaelsen, Meike, Schreiber, Franziska, Haupt, Simone, Peitz, Michael, Brüstle, Oliver, Küpper, Clemens, Klopstock, Thomas, Otto, Markus, Ludolph, Albert C, Arzberger, Thomas, Kuhn, Peer‐Hendrik, Edbauer, Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090220/
https://www.ncbi.nlm.nih.gov/pubmed/27621269
http://dx.doi.org/10.15252/embj.201694221

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