Interaction of benzo[a]pyrene diol epoxide isomers with human serum albumin: Site specific characterisation of adducts and associated kinetics

Carcinogenicity of benzo[a]pyrene {B[a]P, a polycyclic aromatic hydrocarbon (PAH)} involves DNA-modification by B[a]P diol epoxide (BPDE) metabolites. Adducts to serum albumin (SA) are not repaired, unlike DNA adducts, and therefore considered advantageous in assessment of in vivo dose of BPDEs. In...

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Detalles Bibliográficos
Autores principales: Motwani, Hitesh V., Westberg, Emelie, Törnqvist, Margareta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090251/
https://www.ncbi.nlm.nih.gov/pubmed/27805056
http://dx.doi.org/10.1038/srep36243

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090251/
https://www.ncbi.nlm.nih.gov/pubmed/27805056
http://dx.doi.org/10.1038/srep36243

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