A comparison study of different physical treatments on cartilage matrix derived porous scaffolds for tissue engineering applications

Native cartilage matrix derived (CMD) scaffolds from various animal and human sources have drawn attention in cartilage tissue engineering due to the demonstrable presence of bioactive components. Different chemical and physical treatments have been employed to enhance the micro-architecture of CMD...

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Autores principales: Moradi, Ali, Pramanik, Sumit, Ataollahi, Forough, Abdul Khalil, Alizan, Kamarul, Tunku, Pingguan-Murphy, Belinda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090390/
https://www.ncbi.nlm.nih.gov/pubmed/27877731
http://dx.doi.org/10.1088/1468-6996/15/6/065001
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author Moradi, Ali
Pramanik, Sumit
Ataollahi, Forough
Abdul Khalil, Alizan
Kamarul, Tunku
Pingguan-Murphy, Belinda
author_facet Moradi, Ali
Pramanik, Sumit
Ataollahi, Forough
Abdul Khalil, Alizan
Kamarul, Tunku
Pingguan-Murphy, Belinda
author_sort Moradi, Ali
collection PubMed
description Native cartilage matrix derived (CMD) scaffolds from various animal and human sources have drawn attention in cartilage tissue engineering due to the demonstrable presence of bioactive components. Different chemical and physical treatments have been employed to enhance the micro-architecture of CMD scaffolds. In this study we have assessed the typical effects of physical cross-linking methods, namely ultraviolet (UV) light, dehydrothermal (DHT) treatment, and combinations of them on bovine articular CMD porous scaffolds with three different matrix concentrations (5%, 15% and 30%) to assess the relative strengths of each treatment. Our findings suggest that UV and UV–DHT treatments on 15% CMD scaffolds can yield architecturally optimal scaffolds for cartilage tissue engineering.
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spelling pubmed-50903902016-11-22 A comparison study of different physical treatments on cartilage matrix derived porous scaffolds for tissue engineering applications Moradi, Ali Pramanik, Sumit Ataollahi, Forough Abdul Khalil, Alizan Kamarul, Tunku Pingguan-Murphy, Belinda Sci Technol Adv Mater Papers Native cartilage matrix derived (CMD) scaffolds from various animal and human sources have drawn attention in cartilage tissue engineering due to the demonstrable presence of bioactive components. Different chemical and physical treatments have been employed to enhance the micro-architecture of CMD scaffolds. In this study we have assessed the typical effects of physical cross-linking methods, namely ultraviolet (UV) light, dehydrothermal (DHT) treatment, and combinations of them on bovine articular CMD porous scaffolds with three different matrix concentrations (5%, 15% and 30%) to assess the relative strengths of each treatment. Our findings suggest that UV and UV–DHT treatments on 15% CMD scaffolds can yield architecturally optimal scaffolds for cartilage tissue engineering. Taylor & Francis 2014-11-12 /pmc/articles/PMC5090390/ /pubmed/27877731 http://dx.doi.org/10.1088/1468-6996/15/6/065001 Text en © 2014 National Institute for Materials Science http://creativecommons.org/licenses/by/3.0/ Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence (http://creativecommons.org/licenses/by/3.0) . Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.
spellingShingle Papers
Moradi, Ali
Pramanik, Sumit
Ataollahi, Forough
Abdul Khalil, Alizan
Kamarul, Tunku
Pingguan-Murphy, Belinda
A comparison study of different physical treatments on cartilage matrix derived porous scaffolds for tissue engineering applications
title A comparison study of different physical treatments on cartilage matrix derived porous scaffolds for tissue engineering applications
title_full A comparison study of different physical treatments on cartilage matrix derived porous scaffolds for tissue engineering applications
title_fullStr A comparison study of different physical treatments on cartilage matrix derived porous scaffolds for tissue engineering applications
title_full_unstemmed A comparison study of different physical treatments on cartilage matrix derived porous scaffolds for tissue engineering applications
title_short A comparison study of different physical treatments on cartilage matrix derived porous scaffolds for tissue engineering applications
title_sort comparison study of different physical treatments on cartilage matrix derived porous scaffolds for tissue engineering applications
topic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090390/
https://www.ncbi.nlm.nih.gov/pubmed/27877731
http://dx.doi.org/10.1088/1468-6996/15/6/065001
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