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Transjugular intrahepatic portosystemic shunt for Budd–Chiari syndrome with diffuse occlusion of hepatic veins

Either acute or sub-acute Budd–Chiari syndrome (BCS) with diffuse occlusion of hepatic veins has a high mortality rate and remains challenging for clinical treatment. We aimed to evaluate the feasibility and safety of transjugular intrahepatic portosystemic shunt (TIPS) as a treatment for BCS with d...

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Autores principales: He, Fuliang, Zhao, Hongwei, Dai, Shan, Wu, Yingfeng, Wang, Lei, Huang, Hongdong, Yue, Zhendong, Fan, Zhenhua, Dong, Xiaoqun, Liu, Fuquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090639/
https://www.ncbi.nlm.nih.gov/pubmed/27805025
http://dx.doi.org/10.1038/srep36380
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author He, Fuliang
Zhao, Hongwei
Dai, Shan
Wu, Yingfeng
Wang, Lei
Huang, Hongdong
Yue, Zhendong
Fan, Zhenhua
Dong, Xiaoqun
Liu, Fuquan
author_facet He, Fuliang
Zhao, Hongwei
Dai, Shan
Wu, Yingfeng
Wang, Lei
Huang, Hongdong
Yue, Zhendong
Fan, Zhenhua
Dong, Xiaoqun
Liu, Fuquan
author_sort He, Fuliang
collection PubMed
description Either acute or sub-acute Budd–Chiari syndrome (BCS) with diffuse occlusion of hepatic veins has a high mortality rate and remains challenging for clinical treatment. We aimed to evaluate the feasibility and safety of transjugular intrahepatic portosystemic shunt (TIPS) as a treatment for BCS with diffuse occlusion of hepatic veins. From January 2007 to December 2010, 100 patients were randomly recruited onto this study and 91 patients were treated with TIPS. 14 patients were defined as acute BCS group and 86 patients as sub-acute group. Patients with acute BCS had a significantly higher rate of jaundice whereas a lower rate of abdominal and chest varices, gastroesophageal variceal bleeding and refractory ascites than sub-acute group (P < 0.001). TIPS was technically successful in all 91 patients (12 in acute group). The portosystemic pressure gradient (PSG) was decreased to normal level, while total bilirubin (TBIL) and liver function were significantly improved. During follow-up period, the mortality rate of 91 patients who underwent TIPS was 6.59% (6/91), whereas 88.89% of 9 patients who didn’t receive TIPS procedure (2 in acute group). Collectively, TIPS is an effective and safe approach in treating BCS with diffuse occlusion of hepatic veins, which should be performed in time.
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spelling pubmed-50906392016-11-08 Transjugular intrahepatic portosystemic shunt for Budd–Chiari syndrome with diffuse occlusion of hepatic veins He, Fuliang Zhao, Hongwei Dai, Shan Wu, Yingfeng Wang, Lei Huang, Hongdong Yue, Zhendong Fan, Zhenhua Dong, Xiaoqun Liu, Fuquan Sci Rep Article Either acute or sub-acute Budd–Chiari syndrome (BCS) with diffuse occlusion of hepatic veins has a high mortality rate and remains challenging for clinical treatment. We aimed to evaluate the feasibility and safety of transjugular intrahepatic portosystemic shunt (TIPS) as a treatment for BCS with diffuse occlusion of hepatic veins. From January 2007 to December 2010, 100 patients were randomly recruited onto this study and 91 patients were treated with TIPS. 14 patients were defined as acute BCS group and 86 patients as sub-acute group. Patients with acute BCS had a significantly higher rate of jaundice whereas a lower rate of abdominal and chest varices, gastroesophageal variceal bleeding and refractory ascites than sub-acute group (P < 0.001). TIPS was technically successful in all 91 patients (12 in acute group). The portosystemic pressure gradient (PSG) was decreased to normal level, while total bilirubin (TBIL) and liver function were significantly improved. During follow-up period, the mortality rate of 91 patients who underwent TIPS was 6.59% (6/91), whereas 88.89% of 9 patients who didn’t receive TIPS procedure (2 in acute group). Collectively, TIPS is an effective and safe approach in treating BCS with diffuse occlusion of hepatic veins, which should be performed in time. Nature Publishing Group 2016-11-02 /pmc/articles/PMC5090639/ /pubmed/27805025 http://dx.doi.org/10.1038/srep36380 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
He, Fuliang
Zhao, Hongwei
Dai, Shan
Wu, Yingfeng
Wang, Lei
Huang, Hongdong
Yue, Zhendong
Fan, Zhenhua
Dong, Xiaoqun
Liu, Fuquan
Transjugular intrahepatic portosystemic shunt for Budd–Chiari syndrome with diffuse occlusion of hepatic veins
title Transjugular intrahepatic portosystemic shunt for Budd–Chiari syndrome with diffuse occlusion of hepatic veins
title_full Transjugular intrahepatic portosystemic shunt for Budd–Chiari syndrome with diffuse occlusion of hepatic veins
title_fullStr Transjugular intrahepatic portosystemic shunt for Budd–Chiari syndrome with diffuse occlusion of hepatic veins
title_full_unstemmed Transjugular intrahepatic portosystemic shunt for Budd–Chiari syndrome with diffuse occlusion of hepatic veins
title_short Transjugular intrahepatic portosystemic shunt for Budd–Chiari syndrome with diffuse occlusion of hepatic veins
title_sort transjugular intrahepatic portosystemic shunt for budd–chiari syndrome with diffuse occlusion of hepatic veins
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090639/
https://www.ncbi.nlm.nih.gov/pubmed/27805025
http://dx.doi.org/10.1038/srep36380
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