Manipulation of cell membrane using carbon nanotube scaffold as a photoresponsive stimuli generator

We describe, for the first time, the perforation of the cell membrane in the targeted single cell based on the nanosecond pulsed near-infrared (NIR) laser irradiation of a thin film of carbon nanotubes that act as an effective photon absorber as well as stimuli generator. When the power of NIR laser...

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Detalles Bibliográficos
Autores principales: Sada, Takao, Fujigaya, Tsuyohiko, Nakashima, Naotoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090691/
https://www.ncbi.nlm.nih.gov/pubmed/27877703
http://dx.doi.org/10.1088/1468-6996/15/4/045002
Descripción
Sumario:We describe, for the first time, the perforation of the cell membrane in the targeted single cell based on the nanosecond pulsed near-infrared (NIR) laser irradiation of a thin film of carbon nanotubes that act as an effective photon absorber as well as stimuli generator. When the power of NIR laser is over 17.5 μJ/pulse, the cell membrane after irradiation is irreversibly disrupted and results in cell death. In sharp contrast, the perforation of the cell membrane occurs at suitable laser power (∼15 μJ/pulse) without involving cell termination.

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