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Seroprevalence and Risk Factors for Hepatitis B in an Adult Population: The First Report from Birjand, South Khorasan, Iran

BACKGROUND: Infection with the hepatitis B virus (HBV) is an important global health problem. Knowledge of the geographic distribution pattern of HBV infection can help to control the spread of the disease. OBJECTIVES: To determine the prevalence of HBV infections and risk factors for the disease fo...

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Autores principales: Ziaee, Masood, Ebrahimzadeh, Azadeh, Azarkar, Zohreh, Namaei, Mohammad Hasan, Saburi, Amin, Fereidouni, Mohammad, Bijari, Bita, Karamian, Mehdi, Sharifzadeh, Gholamreza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kowsar 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090805/
https://www.ncbi.nlm.nih.gov/pubmed/27822260
http://dx.doi.org/10.5812/hepatmon.36452
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author Ziaee, Masood
Ebrahimzadeh, Azadeh
Azarkar, Zohreh
Namaei, Mohammad Hasan
Saburi, Amin
Fereidouni, Mohammad
Bijari, Bita
Karamian, Mehdi
Sharifzadeh, Gholamreza
author_facet Ziaee, Masood
Ebrahimzadeh, Azadeh
Azarkar, Zohreh
Namaei, Mohammad Hasan
Saburi, Amin
Fereidouni, Mohammad
Bijari, Bita
Karamian, Mehdi
Sharifzadeh, Gholamreza
author_sort Ziaee, Masood
collection PubMed
description BACKGROUND: Infection with the hepatitis B virus (HBV) is an important global health problem. Knowledge of the geographic distribution pattern of HBV infection can help to control the spread of the disease. OBJECTIVES: To determine the prevalence of HBV infections and risk factors for the disease for the first time in Birjand, Southeastern Iran. METHODS: This was an analytical cross-sectional study conducted in 2013 - 2014 of 5235 HBV cases in Birjand, South Khorasan Iran. Subjects aged 15 - 70 y were selected using the cluster sampling method. Blood samples were taken and tested at a reference laboratory for the hepatitis B core antibody (anti-HBc). Seropositive specimens were tested for the hepatitis B surface antigen (HBsAg). RESULTS: The mean age (± SD) was 39.07 (± 14.04) y, and 786 (15%) subjects were anti-HBc positive. The prevalence of HBsAg was 1.6% (n = 85). The prevalence of anti-HBc seropositivity was significantly higher in subjects with a lower level of education (P = 0.09), older subjects (P = 0.001), intravenous (IV) drug users (P<0.05), subjects with piercings (P < 0.001), and subjects with a positive history of familial HBV or HCV infection (P < 0.05). It was also significantly higher in those who drank alcohol (P = 0.09) or had a history of blood transfusions (P = 0.001), cupping (P = 0.004), hospital admission (P = 0.03), or endoscopy (P = 0.002). The rate of HBsAg positivity was significantly higher in subjects with a history of cupping (P=0.03), a positive history of familial HBV or HCV infection (P < 0.05), and older subjects (P = 0.015). CONCLUSIONS: Although the frequency of HBsAg seropositivity in the present study was close to that observed in the overall Iranian population, the seroprevalence of anti-HBc was higher, possibly due to the exposure of the elderly to more risk factors. The risk factors were similar. These included a history of blood transfusions, cupping, hospital admission, endoscopy, or familial HBV/HCV infection, in addition to piercings and drug abuse.
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spelling pubmed-50908052016-11-07 Seroprevalence and Risk Factors for Hepatitis B in an Adult Population: The First Report from Birjand, South Khorasan, Iran Ziaee, Masood Ebrahimzadeh, Azadeh Azarkar, Zohreh Namaei, Mohammad Hasan Saburi, Amin Fereidouni, Mohammad Bijari, Bita Karamian, Mehdi Sharifzadeh, Gholamreza Hepat Mon Research Article BACKGROUND: Infection with the hepatitis B virus (HBV) is an important global health problem. Knowledge of the geographic distribution pattern of HBV infection can help to control the spread of the disease. OBJECTIVES: To determine the prevalence of HBV infections and risk factors for the disease for the first time in Birjand, Southeastern Iran. METHODS: This was an analytical cross-sectional study conducted in 2013 - 2014 of 5235 HBV cases in Birjand, South Khorasan Iran. Subjects aged 15 - 70 y were selected using the cluster sampling method. Blood samples were taken and tested at a reference laboratory for the hepatitis B core antibody (anti-HBc). Seropositive specimens were tested for the hepatitis B surface antigen (HBsAg). RESULTS: The mean age (± SD) was 39.07 (± 14.04) y, and 786 (15%) subjects were anti-HBc positive. The prevalence of HBsAg was 1.6% (n = 85). The prevalence of anti-HBc seropositivity was significantly higher in subjects with a lower level of education (P = 0.09), older subjects (P = 0.001), intravenous (IV) drug users (P<0.05), subjects with piercings (P < 0.001), and subjects with a positive history of familial HBV or HCV infection (P < 0.05). It was also significantly higher in those who drank alcohol (P = 0.09) or had a history of blood transfusions (P = 0.001), cupping (P = 0.004), hospital admission (P = 0.03), or endoscopy (P = 0.002). The rate of HBsAg positivity was significantly higher in subjects with a history of cupping (P=0.03), a positive history of familial HBV or HCV infection (P < 0.05), and older subjects (P = 0.015). CONCLUSIONS: Although the frequency of HBsAg seropositivity in the present study was close to that observed in the overall Iranian population, the seroprevalence of anti-HBc was higher, possibly due to the exposure of the elderly to more risk factors. The risk factors were similar. These included a history of blood transfusions, cupping, hospital admission, endoscopy, or familial HBV/HCV infection, in addition to piercings and drug abuse. Kowsar 2016-08-14 /pmc/articles/PMC5090805/ /pubmed/27822260 http://dx.doi.org/10.5812/hepatmon.36452 Text en Copyright © 2016, Kowsar Corp http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
spellingShingle Research Article
Ziaee, Masood
Ebrahimzadeh, Azadeh
Azarkar, Zohreh
Namaei, Mohammad Hasan
Saburi, Amin
Fereidouni, Mohammad
Bijari, Bita
Karamian, Mehdi
Sharifzadeh, Gholamreza
Seroprevalence and Risk Factors for Hepatitis B in an Adult Population: The First Report from Birjand, South Khorasan, Iran
title Seroprevalence and Risk Factors for Hepatitis B in an Adult Population: The First Report from Birjand, South Khorasan, Iran
title_full Seroprevalence and Risk Factors for Hepatitis B in an Adult Population: The First Report from Birjand, South Khorasan, Iran
title_fullStr Seroprevalence and Risk Factors for Hepatitis B in an Adult Population: The First Report from Birjand, South Khorasan, Iran
title_full_unstemmed Seroprevalence and Risk Factors for Hepatitis B in an Adult Population: The First Report from Birjand, South Khorasan, Iran
title_short Seroprevalence and Risk Factors for Hepatitis B in an Adult Population: The First Report from Birjand, South Khorasan, Iran
title_sort seroprevalence and risk factors for hepatitis b in an adult population: the first report from birjand, south khorasan, iran
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090805/
https://www.ncbi.nlm.nih.gov/pubmed/27822260
http://dx.doi.org/10.5812/hepatmon.36452
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