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Nanobiomaterials for neural regeneration

Diseases and disorders associated with nervous system such as injuries by trauma and neurodegeneration are shown to be one of the most serious problems in medicine, requiring innovative strategies to trigger and enhance the nerve regeneration. Tissue engineering aims to provide a highly biomimetic e...

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Autores principales: Chen, Nuan, Tian, Lingling, He, Liumin, Ramakrishna, Seeram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090823/
https://www.ncbi.nlm.nih.gov/pubmed/27857724
http://dx.doi.org/10.4103/1673-5374.191195
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author Chen, Nuan
Tian, Lingling
He, Liumin
Ramakrishna, Seeram
author_facet Chen, Nuan
Tian, Lingling
He, Liumin
Ramakrishna, Seeram
author_sort Chen, Nuan
collection PubMed
description Diseases and disorders associated with nervous system such as injuries by trauma and neurodegeneration are shown to be one of the most serious problems in medicine, requiring innovative strategies to trigger and enhance the nerve regeneration. Tissue engineering aims to provide a highly biomimetic environment by using a combination of cells, materials and suitable biological cues, by which the lost body part may be regenerated or even fully rebuilt. Electrospinning, being able to produce extracellular matrix (ECM)-like nanostructures with great flexibility in design and choice of materials, have demonstrated their great potential for fabrication of nerve tissue engineered scaffolds. The review here begins with a brief description of the anatomy of native nervous system, which provides basic knowledge and ideas for the design of nerve tissue scaffolds, followed by five main parts in the design of electrospun nerve tissue engineered scaffolds including materials selection, structural design, in vitro bioreactor, functionalization and cellular support. Performances of biomimetic electrospun nanofibrous nerve implant devices are also reviewed. Finally, future directions for advanced electrospun nerve tissue engineered scaffolds are discussed.
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spelling pubmed-50908232016-11-17 Nanobiomaterials for neural regeneration Chen, Nuan Tian, Lingling He, Liumin Ramakrishna, Seeram Neural Regen Res Invited Review Diseases and disorders associated with nervous system such as injuries by trauma and neurodegeneration are shown to be one of the most serious problems in medicine, requiring innovative strategies to trigger and enhance the nerve regeneration. Tissue engineering aims to provide a highly biomimetic environment by using a combination of cells, materials and suitable biological cues, by which the lost body part may be regenerated or even fully rebuilt. Electrospinning, being able to produce extracellular matrix (ECM)-like nanostructures with great flexibility in design and choice of materials, have demonstrated their great potential for fabrication of nerve tissue engineered scaffolds. The review here begins with a brief description of the anatomy of native nervous system, which provides basic knowledge and ideas for the design of nerve tissue scaffolds, followed by five main parts in the design of electrospun nerve tissue engineered scaffolds including materials selection, structural design, in vitro bioreactor, functionalization and cellular support. Performances of biomimetic electrospun nanofibrous nerve implant devices are also reviewed. Finally, future directions for advanced electrospun nerve tissue engineered scaffolds are discussed. Medknow Publications & Media Pvt Ltd 2016-09 /pmc/articles/PMC5090823/ /pubmed/27857724 http://dx.doi.org/10.4103/1673-5374.191195 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Invited Review
Chen, Nuan
Tian, Lingling
He, Liumin
Ramakrishna, Seeram
Nanobiomaterials for neural regeneration
title Nanobiomaterials for neural regeneration
title_full Nanobiomaterials for neural regeneration
title_fullStr Nanobiomaterials for neural regeneration
title_full_unstemmed Nanobiomaterials for neural regeneration
title_short Nanobiomaterials for neural regeneration
title_sort nanobiomaterials for neural regeneration
topic Invited Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090823/
https://www.ncbi.nlm.nih.gov/pubmed/27857724
http://dx.doi.org/10.4103/1673-5374.191195
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