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Sustaining Interferon Induction by a High-Passage Atypical Porcine Reproductive and Respiratory Syndrome Virus Strain

Porcine reproductive and respiratory syndrome virus (PRRSV) strain A2MC2 induces type I interferons in cultured cells. The objective of this study was to attenuate this strain by serial passaging in MARC-145 cells and assess its virulence and immunogenicity in pigs. The A2MC2 serially passaged 90 ti...

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Detalles Bibliográficos
Autores principales:	Ma, Zexu, Yu, Ying, Xiao, Yueqiang, Opriessnig, Tanja, Wang, Rong, Yang, Liping, Nan, Yuchen, Samal, Siba K., Halbur, Patrick G., Zhang, Yan-Jin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090871/ https://www.ncbi.nlm.nih.gov/pubmed/27805024 http://dx.doi.org/10.1038/srep36312

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