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Influenza Virus-Associated Fatal Acute Necrotizing Encephalopathy: Role of Nonpermissive Viral Infection?
In 2014, two unusual peaks of H1N1 influenza outbreak occurred in Nakhon Ratchasima Province, in Thailand. Among 2,406 cases, one of the 22 deaths in the province included a 6-year-old boy, who initially presented with acute necrotizing encephalopathy. On the other hand, his sibling was mildly affec...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Libertas Academica
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5091092/ https://www.ncbi.nlm.nih.gov/pubmed/27812294 http://dx.doi.org/10.4137/CCRep.S40610 |
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author | Mungaomklang, Anek Chomcheoy, Jiraruj Wacharapluesadee, Supaporn Joyjinda, Yutthana Jittmittraphap, Akanitt Rodpan, Apaporn Ghai, Siriporn Saraya, Abhinbhen Hemachudha, Thiravat |
author_facet | Mungaomklang, Anek Chomcheoy, Jiraruj Wacharapluesadee, Supaporn Joyjinda, Yutthana Jittmittraphap, Akanitt Rodpan, Apaporn Ghai, Siriporn Saraya, Abhinbhen Hemachudha, Thiravat |
author_sort | Mungaomklang, Anek |
collection | PubMed |
description | In 2014, two unusual peaks of H1N1 influenza outbreak occurred in Nakhon Ratchasima Province, in Thailand. Among 2,406 cases, one of the 22 deaths in the province included a 6-year-old boy, who initially presented with acute necrotizing encephalopathy. On the other hand, his sibling was mildly affected by the same influenza virus strain, confirmed by whole-genome sequencing, with one silent mutation. Absence of acute necrotizing encephalopathy and other neurological illnesses in the family and the whole province, with near identical whole viral genomic sequences from the two siblings, and an absence of concomitant severe lung infection (cytokine storm) at onset suggest nonpermissive infection as an alternative pathogenetic mechanism of influenza virus. |
format | Online Article Text |
id | pubmed-5091092 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Libertas Academica |
record_format | MEDLINE/PubMed |
spelling | pubmed-50910922016-11-03 Influenza Virus-Associated Fatal Acute Necrotizing Encephalopathy: Role of Nonpermissive Viral Infection? Mungaomklang, Anek Chomcheoy, Jiraruj Wacharapluesadee, Supaporn Joyjinda, Yutthana Jittmittraphap, Akanitt Rodpan, Apaporn Ghai, Siriporn Saraya, Abhinbhen Hemachudha, Thiravat Clin Med Insights Case Rep Case Report In 2014, two unusual peaks of H1N1 influenza outbreak occurred in Nakhon Ratchasima Province, in Thailand. Among 2,406 cases, one of the 22 deaths in the province included a 6-year-old boy, who initially presented with acute necrotizing encephalopathy. On the other hand, his sibling was mildly affected by the same influenza virus strain, confirmed by whole-genome sequencing, with one silent mutation. Absence of acute necrotizing encephalopathy and other neurological illnesses in the family and the whole province, with near identical whole viral genomic sequences from the two siblings, and an absence of concomitant severe lung infection (cytokine storm) at onset suggest nonpermissive infection as an alternative pathogenetic mechanism of influenza virus. Libertas Academica 2016-11-01 /pmc/articles/PMC5091092/ /pubmed/27812294 http://dx.doi.org/10.4137/CCRep.S40610 Text en © 2016 the author(s), publisher and licensee Libertas Academica Ltd. This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 License. |
spellingShingle | Case Report Mungaomklang, Anek Chomcheoy, Jiraruj Wacharapluesadee, Supaporn Joyjinda, Yutthana Jittmittraphap, Akanitt Rodpan, Apaporn Ghai, Siriporn Saraya, Abhinbhen Hemachudha, Thiravat Influenza Virus-Associated Fatal Acute Necrotizing Encephalopathy: Role of Nonpermissive Viral Infection? |
title | Influenza Virus-Associated Fatal Acute Necrotizing Encephalopathy: Role of Nonpermissive Viral Infection? |
title_full | Influenza Virus-Associated Fatal Acute Necrotizing Encephalopathy: Role of Nonpermissive Viral Infection? |
title_fullStr | Influenza Virus-Associated Fatal Acute Necrotizing Encephalopathy: Role of Nonpermissive Viral Infection? |
title_full_unstemmed | Influenza Virus-Associated Fatal Acute Necrotizing Encephalopathy: Role of Nonpermissive Viral Infection? |
title_short | Influenza Virus-Associated Fatal Acute Necrotizing Encephalopathy: Role of Nonpermissive Viral Infection? |
title_sort | influenza virus-associated fatal acute necrotizing encephalopathy: role of nonpermissive viral infection? |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5091092/ https://www.ncbi.nlm.nih.gov/pubmed/27812294 http://dx.doi.org/10.4137/CCRep.S40610 |
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