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Concentrations of Water-Soluble Vitamins in Blood and Urinary Excretion in Patients with Diabetes Mellitus

We examined the concentrations of water-soluble vitamins in blood and urinary excretion of 22 patients with type 2 diabetes mellitus (type 2DM) and 20 healthy control participants. Macronutrient and vitamin intakes of type 2DM subjects were measured using a weighed food record method. Control partic...

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Autores principales: Iwakawa, Hiromi, Nakamura, Yasuyuki, Fukui, Tomiho, Fukuwatari, Tsutomu, Ugi, Satoshi, Maegawa, Hiroshi, Doi, Yukio, Shibata, Katsumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5091094/
https://www.ncbi.nlm.nih.gov/pubmed/27812289
http://dx.doi.org/10.4137/NMI.S40595
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author Iwakawa, Hiromi
Nakamura, Yasuyuki
Fukui, Tomiho
Fukuwatari, Tsutomu
Ugi, Satoshi
Maegawa, Hiroshi
Doi, Yukio
Shibata, Katsumi
author_facet Iwakawa, Hiromi
Nakamura, Yasuyuki
Fukui, Tomiho
Fukuwatari, Tsutomu
Ugi, Satoshi
Maegawa, Hiroshi
Doi, Yukio
Shibata, Katsumi
author_sort Iwakawa, Hiromi
collection PubMed
description We examined the concentrations of water-soluble vitamins in blood and urinary excretion of 22 patients with type 2 diabetes mellitus (type 2DM) and 20 healthy control participants. Macronutrient and vitamin intakes of type 2DM subjects were measured using a weighed food record method. Control participants consumed a semipurified diet for eight days. Multiple linear regression models were used to determine whether significant differences existed in vitamin concentrations in blood independent of age, sex, and other confounding factors. Concentrations of vitamins B2, B6, C, niacin, and folate in blood were significantly lower in type 2DM subjects than in controls, independent of confounding factors. Renal clearances of vitamins B6, C, niacin, and folate were significantly higher in type 2DM subjects than in controls. In conclusion, concentrations of vitamins B2, B6, C, niacin, and folate in blood were significantly lower in type 2DM subjects than in controls, independent of confounding factors; based on the evidence of increased urinary clearance of these vitamins, the lower levels were likely due to impaired reabsorption processes.
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spelling pubmed-50910942016-11-03 Concentrations of Water-Soluble Vitamins in Blood and Urinary Excretion in Patients with Diabetes Mellitus Iwakawa, Hiromi Nakamura, Yasuyuki Fukui, Tomiho Fukuwatari, Tsutomu Ugi, Satoshi Maegawa, Hiroshi Doi, Yukio Shibata, Katsumi Nutr Metab Insights Original Research We examined the concentrations of water-soluble vitamins in blood and urinary excretion of 22 patients with type 2 diabetes mellitus (type 2DM) and 20 healthy control participants. Macronutrient and vitamin intakes of type 2DM subjects were measured using a weighed food record method. Control participants consumed a semipurified diet for eight days. Multiple linear regression models were used to determine whether significant differences existed in vitamin concentrations in blood independent of age, sex, and other confounding factors. Concentrations of vitamins B2, B6, C, niacin, and folate in blood were significantly lower in type 2DM subjects than in controls, independent of confounding factors. Renal clearances of vitamins B6, C, niacin, and folate were significantly higher in type 2DM subjects than in controls. In conclusion, concentrations of vitamins B2, B6, C, niacin, and folate in blood were significantly lower in type 2DM subjects than in controls, independent of confounding factors; based on the evidence of increased urinary clearance of these vitamins, the lower levels were likely due to impaired reabsorption processes. Libertas Academica 2016-11-01 /pmc/articles/PMC5091094/ /pubmed/27812289 http://dx.doi.org/10.4137/NMI.S40595 Text en © 2016 the author(s), publisher and licensee Libertas Academica Ltd. This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 License.
spellingShingle Original Research
Iwakawa, Hiromi
Nakamura, Yasuyuki
Fukui, Tomiho
Fukuwatari, Tsutomu
Ugi, Satoshi
Maegawa, Hiroshi
Doi, Yukio
Shibata, Katsumi
Concentrations of Water-Soluble Vitamins in Blood and Urinary Excretion in Patients with Diabetes Mellitus
title Concentrations of Water-Soluble Vitamins in Blood and Urinary Excretion in Patients with Diabetes Mellitus
title_full Concentrations of Water-Soluble Vitamins in Blood and Urinary Excretion in Patients with Diabetes Mellitus
title_fullStr Concentrations of Water-Soluble Vitamins in Blood and Urinary Excretion in Patients with Diabetes Mellitus
title_full_unstemmed Concentrations of Water-Soluble Vitamins in Blood and Urinary Excretion in Patients with Diabetes Mellitus
title_short Concentrations of Water-Soluble Vitamins in Blood and Urinary Excretion in Patients with Diabetes Mellitus
title_sort concentrations of water-soluble vitamins in blood and urinary excretion in patients with diabetes mellitus
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5091094/
https://www.ncbi.nlm.nih.gov/pubmed/27812289
http://dx.doi.org/10.4137/NMI.S40595
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