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Concentrations of Water-Soluble Vitamins in Blood and Urinary Excretion in Patients with Diabetes Mellitus
We examined the concentrations of water-soluble vitamins in blood and urinary excretion of 22 patients with type 2 diabetes mellitus (type 2DM) and 20 healthy control participants. Macronutrient and vitamin intakes of type 2DM subjects were measured using a weighed food record method. Control partic...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Libertas Academica
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5091094/ https://www.ncbi.nlm.nih.gov/pubmed/27812289 http://dx.doi.org/10.4137/NMI.S40595 |
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author | Iwakawa, Hiromi Nakamura, Yasuyuki Fukui, Tomiho Fukuwatari, Tsutomu Ugi, Satoshi Maegawa, Hiroshi Doi, Yukio Shibata, Katsumi |
author_facet | Iwakawa, Hiromi Nakamura, Yasuyuki Fukui, Tomiho Fukuwatari, Tsutomu Ugi, Satoshi Maegawa, Hiroshi Doi, Yukio Shibata, Katsumi |
author_sort | Iwakawa, Hiromi |
collection | PubMed |
description | We examined the concentrations of water-soluble vitamins in blood and urinary excretion of 22 patients with type 2 diabetes mellitus (type 2DM) and 20 healthy control participants. Macronutrient and vitamin intakes of type 2DM subjects were measured using a weighed food record method. Control participants consumed a semipurified diet for eight days. Multiple linear regression models were used to determine whether significant differences existed in vitamin concentrations in blood independent of age, sex, and other confounding factors. Concentrations of vitamins B2, B6, C, niacin, and folate in blood were significantly lower in type 2DM subjects than in controls, independent of confounding factors. Renal clearances of vitamins B6, C, niacin, and folate were significantly higher in type 2DM subjects than in controls. In conclusion, concentrations of vitamins B2, B6, C, niacin, and folate in blood were significantly lower in type 2DM subjects than in controls, independent of confounding factors; based on the evidence of increased urinary clearance of these vitamins, the lower levels were likely due to impaired reabsorption processes. |
format | Online Article Text |
id | pubmed-5091094 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Libertas Academica |
record_format | MEDLINE/PubMed |
spelling | pubmed-50910942016-11-03 Concentrations of Water-Soluble Vitamins in Blood and Urinary Excretion in Patients with Diabetes Mellitus Iwakawa, Hiromi Nakamura, Yasuyuki Fukui, Tomiho Fukuwatari, Tsutomu Ugi, Satoshi Maegawa, Hiroshi Doi, Yukio Shibata, Katsumi Nutr Metab Insights Original Research We examined the concentrations of water-soluble vitamins in blood and urinary excretion of 22 patients with type 2 diabetes mellitus (type 2DM) and 20 healthy control participants. Macronutrient and vitamin intakes of type 2DM subjects were measured using a weighed food record method. Control participants consumed a semipurified diet for eight days. Multiple linear regression models were used to determine whether significant differences existed in vitamin concentrations in blood independent of age, sex, and other confounding factors. Concentrations of vitamins B2, B6, C, niacin, and folate in blood were significantly lower in type 2DM subjects than in controls, independent of confounding factors. Renal clearances of vitamins B6, C, niacin, and folate were significantly higher in type 2DM subjects than in controls. In conclusion, concentrations of vitamins B2, B6, C, niacin, and folate in blood were significantly lower in type 2DM subjects than in controls, independent of confounding factors; based on the evidence of increased urinary clearance of these vitamins, the lower levels were likely due to impaired reabsorption processes. Libertas Academica 2016-11-01 /pmc/articles/PMC5091094/ /pubmed/27812289 http://dx.doi.org/10.4137/NMI.S40595 Text en © 2016 the author(s), publisher and licensee Libertas Academica Ltd. This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 License. |
spellingShingle | Original Research Iwakawa, Hiromi Nakamura, Yasuyuki Fukui, Tomiho Fukuwatari, Tsutomu Ugi, Satoshi Maegawa, Hiroshi Doi, Yukio Shibata, Katsumi Concentrations of Water-Soluble Vitamins in Blood and Urinary Excretion in Patients with Diabetes Mellitus |
title | Concentrations of Water-Soluble Vitamins in Blood and Urinary Excretion in Patients with Diabetes Mellitus |
title_full | Concentrations of Water-Soluble Vitamins in Blood and Urinary Excretion in Patients with Diabetes Mellitus |
title_fullStr | Concentrations of Water-Soluble Vitamins in Blood and Urinary Excretion in Patients with Diabetes Mellitus |
title_full_unstemmed | Concentrations of Water-Soluble Vitamins in Blood and Urinary Excretion in Patients with Diabetes Mellitus |
title_short | Concentrations of Water-Soluble Vitamins in Blood and Urinary Excretion in Patients with Diabetes Mellitus |
title_sort | concentrations of water-soluble vitamins in blood and urinary excretion in patients with diabetes mellitus |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5091094/ https://www.ncbi.nlm.nih.gov/pubmed/27812289 http://dx.doi.org/10.4137/NMI.S40595 |
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