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Cirrhotic Cardiomyopathy: Another Case of a Successful Approach to Treatment of Hepatorenal Syndrome

Hepatorenal syndrome (HRS) is defined as a failure of renal function, potentially reversible, in patients with liver cirrhosis and ascites. Recently, a component of cardiomyopathy associated with HRS was described, but the use of positive inotropic medicine as part of the treatment of the acute phas...

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Autores principales: Mocarzel, Luis Otávio, Bicca, Jessica, Jarske, Luiza, Oliveira, Thamires, Lanzieri, Pedro, Gismondi, Ronaldo, Ribeiro, Mario Luiz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5091268/
https://www.ncbi.nlm.nih.gov/pubmed/27843430
http://dx.doi.org/10.1159/000448885
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author Mocarzel, Luis Otávio
Bicca, Jessica
Jarske, Luiza
Oliveira, Thamires
Lanzieri, Pedro
Gismondi, Ronaldo
Ribeiro, Mario Luiz
author_facet Mocarzel, Luis Otávio
Bicca, Jessica
Jarske, Luiza
Oliveira, Thamires
Lanzieri, Pedro
Gismondi, Ronaldo
Ribeiro, Mario Luiz
author_sort Mocarzel, Luis Otávio
collection PubMed
description Hepatorenal syndrome (HRS) is defined as a failure of renal function, potentially reversible, in patients with liver cirrhosis and ascites. Recently, a component of cardiomyopathy associated with HRS was described, but the use of positive inotropic medicine as part of the treatment of the acute phase has not been extensively evaluated. We report a second case in our hospital of a patient with HRS type I without previous heart disease, with secondary hemodynamic decompensation due to liver disease, in which the abnormalities in systolic function by speckle-tracking echocardiography were observed and could be reversed by the use of inotropes. After partial response to current therapies, the patient presented a clinical and laboratorial response with improvement of renal function after infusion of dobutamine. Clinical studies are needed for the therapy approach to HRS taking into account myocardial dysfunction as a major contributing factor for renal dysfunction.
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spelling pubmed-50912682016-11-14 Cirrhotic Cardiomyopathy: Another Case of a Successful Approach to Treatment of Hepatorenal Syndrome Mocarzel, Luis Otávio Bicca, Jessica Jarske, Luiza Oliveira, Thamires Lanzieri, Pedro Gismondi, Ronaldo Ribeiro, Mario Luiz Case Rep Gastroenterol Single Case Hepatorenal syndrome (HRS) is defined as a failure of renal function, potentially reversible, in patients with liver cirrhosis and ascites. Recently, a component of cardiomyopathy associated with HRS was described, but the use of positive inotropic medicine as part of the treatment of the acute phase has not been extensively evaluated. We report a second case in our hospital of a patient with HRS type I without previous heart disease, with secondary hemodynamic decompensation due to liver disease, in which the abnormalities in systolic function by speckle-tracking echocardiography were observed and could be reversed by the use of inotropes. After partial response to current therapies, the patient presented a clinical and laboratorial response with improvement of renal function after infusion of dobutamine. Clinical studies are needed for the therapy approach to HRS taking into account myocardial dysfunction as a major contributing factor for renal dysfunction. S. Karger AG 2016-10-10 /pmc/articles/PMC5091268/ /pubmed/27843430 http://dx.doi.org/10.1159/000448885 Text en Copyright © 2016 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Single Case
Mocarzel, Luis Otávio
Bicca, Jessica
Jarske, Luiza
Oliveira, Thamires
Lanzieri, Pedro
Gismondi, Ronaldo
Ribeiro, Mario Luiz
Cirrhotic Cardiomyopathy: Another Case of a Successful Approach to Treatment of Hepatorenal Syndrome
title Cirrhotic Cardiomyopathy: Another Case of a Successful Approach to Treatment of Hepatorenal Syndrome
title_full Cirrhotic Cardiomyopathy: Another Case of a Successful Approach to Treatment of Hepatorenal Syndrome
title_fullStr Cirrhotic Cardiomyopathy: Another Case of a Successful Approach to Treatment of Hepatorenal Syndrome
title_full_unstemmed Cirrhotic Cardiomyopathy: Another Case of a Successful Approach to Treatment of Hepatorenal Syndrome
title_short Cirrhotic Cardiomyopathy: Another Case of a Successful Approach to Treatment of Hepatorenal Syndrome
title_sort cirrhotic cardiomyopathy: another case of a successful approach to treatment of hepatorenal syndrome
topic Single Case
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5091268/
https://www.ncbi.nlm.nih.gov/pubmed/27843430
http://dx.doi.org/10.1159/000448885
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