HAUSP deubiquitinated and stabilizes N-Myc in neuroblastoma

The MYCN protooncogene is amplified in a number of advanced-stage human tumors such as neuroblastomas. Like other members of Myc family proteins, N-Myc is a transcription factor and its stability and activity are tightly controlled by ubiquitination-dependent proteasome degradation(1-4). Although nu...

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Detalles Bibliográficos
Autores principales: Tavana, Omid, Li, Dawei, Dai, Chao, Lopez, Gonzalo, Banerjee, Debarshi, Kon, Ning, Chen, Chao, Califano, Andrea, Yamashiro, Darrell J, Sun, Hongbin, Gu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5091299/
https://www.ncbi.nlm.nih.gov/pubmed/27618649
http://dx.doi.org/10.1038/nm.4180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5091299/
https://www.ncbi.nlm.nih.gov/pubmed/27618649
http://dx.doi.org/10.1038/nm.4180

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