Clinical Effects of a Topically Applied Toll-like Receptor 9 Agonist in Active Moderate-to-Severe Ulcerative Colitis

BACKGROUND AND AIMS: Toll-like receptors [TLRs] are potential drug targets for immunomodulation. We determined the safety and efficacy of the TLR-9 agonist DNA-based immunomodulatory sequence 0150 [DIMS0150] in ulcerative colitis [UC] patients refractory to standard therapy. METHODS: In this randomi...

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Detalles Bibliográficos
Autores principales: Atreya, Raja, Bloom, Stuart, Scaldaferri, Franco, Gerardi, Viviana, Admyre, Charlotte, Karlsson, Åsa, Knittel, Thomas, Kowalski, Jan, Lukas, Milan, Löfberg, Robert, Nancey, Stephane, Petryka, Robert, Rydzewska, Grazyna, Schnabel, Robert, Seidler, Ursula, Neurath, Markus F., Hawkey, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5091328/
https://www.ncbi.nlm.nih.gov/pubmed/27208386
http://dx.doi.org/10.1093/ecco-jcc/jjw103

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