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Prevalence of arterial stiffness and the risk of myocardial diastolic dysfunction in women

The present study determines the prevalence of vascular dysfunction and arterial stiffness (ASt) in a female urban population by measuring the brachial augmentation index (AIx) and aortic pulse wave velocity (PWV). The study tests the hypothesis that the measurement of AIx and PWV is useful in addit...

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Autores principales: Seeland, Ute, Brecht, Anna, Nauman, Ahmad T., Oertelt-Prigione, Sabine, Ruecke, Mirjam, Knebel, Fabian, Stangl, Verena, Regitz-Zagrosek, Vera
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5091468/
https://www.ncbi.nlm.nih.gov/pubmed/27653526
http://dx.doi.org/10.1042/BSR20160276
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author Seeland, Ute
Brecht, Anna
Nauman, Ahmad T.
Oertelt-Prigione, Sabine
Ruecke, Mirjam
Knebel, Fabian
Stangl, Verena
Regitz-Zagrosek, Vera
author_facet Seeland, Ute
Brecht, Anna
Nauman, Ahmad T.
Oertelt-Prigione, Sabine
Ruecke, Mirjam
Knebel, Fabian
Stangl, Verena
Regitz-Zagrosek, Vera
author_sort Seeland, Ute
collection PubMed
description The present study determines the prevalence of vascular dysfunction and arterial stiffness (ASt) in a female urban population by measuring the brachial augmentation index (AIx) and aortic pulse wave velocity (PWV). The study tests the hypothesis that the measurement of AIx and PWV is useful in addition to that of traditional cardiovascular risk factors when assessing the risk for left ventricular diastolic dysfunction (LVDD). This cross-sectional study recruited 965 women aged 25–75 years from 12 districts of Berlin. The ASt indices, brachial AIx, aortic PWV and the central blood pressure were measured by an oscillometric method. A randomly selected subgroup (n=343) was examined by echocardiography. Trans-mitral inflow E/A ratio and diastolic mitral annulus velocity (é) were assessed. Questionnaires, medical history and blood sampling were used for the evaluation of individual risk factors. Normal vascular function was found in 55% of the women included. The prevalence of women with pathological AIx only (AIx ⩾ −10%, PWV normal) was 21.5%, whereas 17.9% were affected by increased AIx and PWV (AIx ⩾ −10%, PWV ⩾9.7 m/s), and 6% with only pathological PWV values. The prevalence of LVDD was 31.7%. LVDD was significantly associated with pathological PWV ⩾ 9.7 m/s [OR: 1.27, 95%CI: 1.02–1.57], age [OR: 4.17, 95%CI: 2.87–6.07] and a waist circumference >80 cm [OR: 3.61, 95%CI: 1.85–7.04] in multiple regression analysis. The high prevalence of markers for vascular dysfunction and ASt in a general female population and their importance as a mediator of diastolic dysfunction should encourage implementation of aortic PWV measurement to improve cardiovascular-risk assessment in particular to identify subclinical myocardial diastolic dysfunction.
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spelling pubmed-50914682016-11-08 Prevalence of arterial stiffness and the risk of myocardial diastolic dysfunction in women Seeland, Ute Brecht, Anna Nauman, Ahmad T. Oertelt-Prigione, Sabine Ruecke, Mirjam Knebel, Fabian Stangl, Verena Regitz-Zagrosek, Vera Biosci Rep Original Papers The present study determines the prevalence of vascular dysfunction and arterial stiffness (ASt) in a female urban population by measuring the brachial augmentation index (AIx) and aortic pulse wave velocity (PWV). The study tests the hypothesis that the measurement of AIx and PWV is useful in addition to that of traditional cardiovascular risk factors when assessing the risk for left ventricular diastolic dysfunction (LVDD). This cross-sectional study recruited 965 women aged 25–75 years from 12 districts of Berlin. The ASt indices, brachial AIx, aortic PWV and the central blood pressure were measured by an oscillometric method. A randomly selected subgroup (n=343) was examined by echocardiography. Trans-mitral inflow E/A ratio and diastolic mitral annulus velocity (é) were assessed. Questionnaires, medical history and blood sampling were used for the evaluation of individual risk factors. Normal vascular function was found in 55% of the women included. The prevalence of women with pathological AIx only (AIx ⩾ −10%, PWV normal) was 21.5%, whereas 17.9% were affected by increased AIx and PWV (AIx ⩾ −10%, PWV ⩾9.7 m/s), and 6% with only pathological PWV values. The prevalence of LVDD was 31.7%. LVDD was significantly associated with pathological PWV ⩾ 9.7 m/s [OR: 1.27, 95%CI: 1.02–1.57], age [OR: 4.17, 95%CI: 2.87–6.07] and a waist circumference >80 cm [OR: 3.61, 95%CI: 1.85–7.04] in multiple regression analysis. The high prevalence of markers for vascular dysfunction and ASt in a general female population and their importance as a mediator of diastolic dysfunction should encourage implementation of aortic PWV measurement to improve cardiovascular-risk assessment in particular to identify subclinical myocardial diastolic dysfunction. Portland Press Ltd. 2016-10-27 /pmc/articles/PMC5091468/ /pubmed/27653526 http://dx.doi.org/10.1042/BSR20160276 Text en © 2016 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution Licence 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Papers
Seeland, Ute
Brecht, Anna
Nauman, Ahmad T.
Oertelt-Prigione, Sabine
Ruecke, Mirjam
Knebel, Fabian
Stangl, Verena
Regitz-Zagrosek, Vera
Prevalence of arterial stiffness and the risk of myocardial diastolic dysfunction in women
title Prevalence of arterial stiffness and the risk of myocardial diastolic dysfunction in women
title_full Prevalence of arterial stiffness and the risk of myocardial diastolic dysfunction in women
title_fullStr Prevalence of arterial stiffness and the risk of myocardial diastolic dysfunction in women
title_full_unstemmed Prevalence of arterial stiffness and the risk of myocardial diastolic dysfunction in women
title_short Prevalence of arterial stiffness and the risk of myocardial diastolic dysfunction in women
title_sort prevalence of arterial stiffness and the risk of myocardial diastolic dysfunction in women
topic Original Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5091468/
https://www.ncbi.nlm.nih.gov/pubmed/27653526
http://dx.doi.org/10.1042/BSR20160276
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