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Prevalence of arterial stiffness and the risk of myocardial diastolic dysfunction in women
The present study determines the prevalence of vascular dysfunction and arterial stiffness (ASt) in a female urban population by measuring the brachial augmentation index (AIx) and aortic pulse wave velocity (PWV). The study tests the hypothesis that the measurement of AIx and PWV is useful in addit...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5091468/ https://www.ncbi.nlm.nih.gov/pubmed/27653526 http://dx.doi.org/10.1042/BSR20160276 |
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author | Seeland, Ute Brecht, Anna Nauman, Ahmad T. Oertelt-Prigione, Sabine Ruecke, Mirjam Knebel, Fabian Stangl, Verena Regitz-Zagrosek, Vera |
author_facet | Seeland, Ute Brecht, Anna Nauman, Ahmad T. Oertelt-Prigione, Sabine Ruecke, Mirjam Knebel, Fabian Stangl, Verena Regitz-Zagrosek, Vera |
author_sort | Seeland, Ute |
collection | PubMed |
description | The present study determines the prevalence of vascular dysfunction and arterial stiffness (ASt) in a female urban population by measuring the brachial augmentation index (AIx) and aortic pulse wave velocity (PWV). The study tests the hypothesis that the measurement of AIx and PWV is useful in addition to that of traditional cardiovascular risk factors when assessing the risk for left ventricular diastolic dysfunction (LVDD). This cross-sectional study recruited 965 women aged 25–75 years from 12 districts of Berlin. The ASt indices, brachial AIx, aortic PWV and the central blood pressure were measured by an oscillometric method. A randomly selected subgroup (n=343) was examined by echocardiography. Trans-mitral inflow E/A ratio and diastolic mitral annulus velocity (é) were assessed. Questionnaires, medical history and blood sampling were used for the evaluation of individual risk factors. Normal vascular function was found in 55% of the women included. The prevalence of women with pathological AIx only (AIx ⩾ −10%, PWV normal) was 21.5%, whereas 17.9% were affected by increased AIx and PWV (AIx ⩾ −10%, PWV ⩾9.7 m/s), and 6% with only pathological PWV values. The prevalence of LVDD was 31.7%. LVDD was significantly associated with pathological PWV ⩾ 9.7 m/s [OR: 1.27, 95%CI: 1.02–1.57], age [OR: 4.17, 95%CI: 2.87–6.07] and a waist circumference >80 cm [OR: 3.61, 95%CI: 1.85–7.04] in multiple regression analysis. The high prevalence of markers for vascular dysfunction and ASt in a general female population and their importance as a mediator of diastolic dysfunction should encourage implementation of aortic PWV measurement to improve cardiovascular-risk assessment in particular to identify subclinical myocardial diastolic dysfunction. |
format | Online Article Text |
id | pubmed-5091468 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-50914682016-11-08 Prevalence of arterial stiffness and the risk of myocardial diastolic dysfunction in women Seeland, Ute Brecht, Anna Nauman, Ahmad T. Oertelt-Prigione, Sabine Ruecke, Mirjam Knebel, Fabian Stangl, Verena Regitz-Zagrosek, Vera Biosci Rep Original Papers The present study determines the prevalence of vascular dysfunction and arterial stiffness (ASt) in a female urban population by measuring the brachial augmentation index (AIx) and aortic pulse wave velocity (PWV). The study tests the hypothesis that the measurement of AIx and PWV is useful in addition to that of traditional cardiovascular risk factors when assessing the risk for left ventricular diastolic dysfunction (LVDD). This cross-sectional study recruited 965 women aged 25–75 years from 12 districts of Berlin. The ASt indices, brachial AIx, aortic PWV and the central blood pressure were measured by an oscillometric method. A randomly selected subgroup (n=343) was examined by echocardiography. Trans-mitral inflow E/A ratio and diastolic mitral annulus velocity (é) were assessed. Questionnaires, medical history and blood sampling were used for the evaluation of individual risk factors. Normal vascular function was found in 55% of the women included. The prevalence of women with pathological AIx only (AIx ⩾ −10%, PWV normal) was 21.5%, whereas 17.9% were affected by increased AIx and PWV (AIx ⩾ −10%, PWV ⩾9.7 m/s), and 6% with only pathological PWV values. The prevalence of LVDD was 31.7%. LVDD was significantly associated with pathological PWV ⩾ 9.7 m/s [OR: 1.27, 95%CI: 1.02–1.57], age [OR: 4.17, 95%CI: 2.87–6.07] and a waist circumference >80 cm [OR: 3.61, 95%CI: 1.85–7.04] in multiple regression analysis. The high prevalence of markers for vascular dysfunction and ASt in a general female population and their importance as a mediator of diastolic dysfunction should encourage implementation of aortic PWV measurement to improve cardiovascular-risk assessment in particular to identify subclinical myocardial diastolic dysfunction. Portland Press Ltd. 2016-10-27 /pmc/articles/PMC5091468/ /pubmed/27653526 http://dx.doi.org/10.1042/BSR20160276 Text en © 2016 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution Licence 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Papers Seeland, Ute Brecht, Anna Nauman, Ahmad T. Oertelt-Prigione, Sabine Ruecke, Mirjam Knebel, Fabian Stangl, Verena Regitz-Zagrosek, Vera Prevalence of arterial stiffness and the risk of myocardial diastolic dysfunction in women |
title | Prevalence of arterial stiffness and the risk of myocardial diastolic dysfunction in women |
title_full | Prevalence of arterial stiffness and the risk of myocardial diastolic dysfunction in women |
title_fullStr | Prevalence of arterial stiffness and the risk of myocardial diastolic dysfunction in women |
title_full_unstemmed | Prevalence of arterial stiffness and the risk of myocardial diastolic dysfunction in women |
title_short | Prevalence of arterial stiffness and the risk of myocardial diastolic dysfunction in women |
title_sort | prevalence of arterial stiffness and the risk of myocardial diastolic dysfunction in women |
topic | Original Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5091468/ https://www.ncbi.nlm.nih.gov/pubmed/27653526 http://dx.doi.org/10.1042/BSR20160276 |
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