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Differential renal effects of candesartan at high and ultra-high doses in diabetic mice–potential role of the ACE2/AT2R/Mas axis

High doses of Ang II receptor (AT1R) blockers (ARBs) are renoprotective in diabetes. Underlying mechanisms remain unclear. We evaluated whether high/ultra-high doses of candesartan (ARB) up-regulate angiotensin-converting enzyme 2 (ACE2)/Ang II type 2 receptor (AT2R)/Mas receptor [protective axis of...

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Detalles Bibliográficos
Autores principales:	Callera, Glaucia E., Antunes, Tayze T., Correa, Jose W., Moorman, Danielle, Gutsol, Alexey, He, Ying, Cat, Aurelie Nguyen Dinh, Briones, Ana M., Montezano, Augusto C., Burns, Kevin D., Touyz, Rhian M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2016
Materias:	Original Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5091470/ https://www.ncbi.nlm.nih.gov/pubmed/27612496 http://dx.doi.org/10.1042/BSR20160344

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