TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions

TP53 truncating mutations are common in human tumors and are thought to give rise to p53-null alleles. Here, we show that TP53 exon-6 truncating mutations occur at higher than expected frequencies and produce proteins that lack canonical p53 tumor suppressor activities but promote cancer cell prolif...

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Detalles Bibliográficos
Autores principales: Shirole, Nitin H, Pal, Debjani, Kastenhuber, Edward R, Senturk, Serif, Boroda, Joseph, Pisterzi, Paola, Miller, Madison, Munoz, Gustavo, Anderluh, Marko, Ladanyi, Marc, Lowe, Scott W, Sordella, Raffaella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5092050/
https://www.ncbi.nlm.nih.gov/pubmed/27759562
http://dx.doi.org/10.7554/eLife.17929

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