p19( Arf) Suppresses Growth, Progression, and Metastasis of Hras-Driven Carcinomas through p53-Dependent and -Independent Pathways

Ectopic expression of oncogenes such as Ras induces expression of p19(Arf), which, in turn, activates p53 and growth arrest. Here, we used a multistage model of squamous cell carcinoma development to investigate the functional interactions between Ras, p19(Arf), and p53 during tumor progression in t...

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Detalles Bibliográficos
Autores principales: Kelly-Spratt, Karen S, Gurley, Kay E, Yasui, Yutaka, Kemp, Christopher J
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2004
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC509304/
https://www.ncbi.nlm.nih.gov/pubmed/15314658
http://dx.doi.org/10.1371/journal.pbio.0020242

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC509304/
https://www.ncbi.nlm.nih.gov/pubmed/15314658
http://dx.doi.org/10.1371/journal.pbio.0020242

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