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Leukemic survival factor SALL4 contributes to defective DNA damage repair

SALL4 is aberrantly expressed in human myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). We have generated a SALL4 transgenic (SALL4B Tg) mouse model with pre-leukemic MDS-like symptoms that transform to AML over time. This makes our mouse model applicable for studying human MDS/AML...

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Detalles Bibliográficos
Autores principales:	Wang, Fei, Gao, Chong, Lu, Jiayun, Tatetsu, Hiro, Williams, David A., Müller, Lars U, Cui, Wei, Chai, Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093088/ https://www.ncbi.nlm.nih.gov/pubmed/27132514 http://dx.doi.org/10.1038/onc.2016.146

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