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Functional Connectivity Substrates for tDCS Response in Minimally Conscious State Patients

Transcranial direct current stimulation (tDCS) is a non-invasive technique recently employed in disorders of consciousness, and determining a transitory recovery of signs of consciousness in almost half of minimally conscious state (MCS) patients. Although the rising evidences about its possible rol...

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Autores principales: Cavaliere, Carlo, Aiello, Marco, Di Perri, Carol, Amico, Enrico, Martial, Charlotte, Thibaut, Aurore, Laureys, Steven, Soddu, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093112/
https://www.ncbi.nlm.nih.gov/pubmed/27857682
http://dx.doi.org/10.3389/fncel.2016.00257
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author Cavaliere, Carlo
Aiello, Marco
Di Perri, Carol
Amico, Enrico
Martial, Charlotte
Thibaut, Aurore
Laureys, Steven
Soddu, Andrea
author_facet Cavaliere, Carlo
Aiello, Marco
Di Perri, Carol
Amico, Enrico
Martial, Charlotte
Thibaut, Aurore
Laureys, Steven
Soddu, Andrea
author_sort Cavaliere, Carlo
collection PubMed
description Transcranial direct current stimulation (tDCS) is a non-invasive technique recently employed in disorders of consciousness, and determining a transitory recovery of signs of consciousness in almost half of minimally conscious state (MCS) patients. Although the rising evidences about its possible role in the treatment of many neurological and psychiatric conditions exist, no evidences exist about brain functional connectivity substrates underlying tDCS response. We retrospectively evaluated resting state functional Magnetic Resonance Imaging (fMRI) of 16 sub-acute and chronic MCS patients (6 tDCS responders) who successively received a single left dorsolateral prefrontal cortex (DLPFC) tDCS in a double-blind randomized cross-over trial. A seed-based approach for regions of left extrinsic control network (ECN) and default-mode network (DMN) was performed. tDCS responders showed an increased left intra-network connectivity for regions co-activated with left DLPFC, and significantly with left inferior frontal gyrus. Non-responders (NR) MCS patients showed an increased connectivity between left DLPFC and midline cortical structures, including anterior cingulate cortex and precuneus. Our findings suggest that a prior high connectivity with regions belonging to ECN can facilitate transitory recovery of consciousness in a subgroup of MCS patients that underwent tDCS treatment. Therefore, resting state-fMRI could be very valuable in detecting the neuronal conditions necessary for tDCS to improve behavior in MCS.
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spelling pubmed-50931122016-11-17 Functional Connectivity Substrates for tDCS Response in Minimally Conscious State Patients Cavaliere, Carlo Aiello, Marco Di Perri, Carol Amico, Enrico Martial, Charlotte Thibaut, Aurore Laureys, Steven Soddu, Andrea Front Cell Neurosci Neuroscience Transcranial direct current stimulation (tDCS) is a non-invasive technique recently employed in disorders of consciousness, and determining a transitory recovery of signs of consciousness in almost half of minimally conscious state (MCS) patients. Although the rising evidences about its possible role in the treatment of many neurological and psychiatric conditions exist, no evidences exist about brain functional connectivity substrates underlying tDCS response. We retrospectively evaluated resting state functional Magnetic Resonance Imaging (fMRI) of 16 sub-acute and chronic MCS patients (6 tDCS responders) who successively received a single left dorsolateral prefrontal cortex (DLPFC) tDCS in a double-blind randomized cross-over trial. A seed-based approach for regions of left extrinsic control network (ECN) and default-mode network (DMN) was performed. tDCS responders showed an increased left intra-network connectivity for regions co-activated with left DLPFC, and significantly with left inferior frontal gyrus. Non-responders (NR) MCS patients showed an increased connectivity between left DLPFC and midline cortical structures, including anterior cingulate cortex and precuneus. Our findings suggest that a prior high connectivity with regions belonging to ECN can facilitate transitory recovery of consciousness in a subgroup of MCS patients that underwent tDCS treatment. Therefore, resting state-fMRI could be very valuable in detecting the neuronal conditions necessary for tDCS to improve behavior in MCS. Frontiers Media S.A. 2016-11-03 /pmc/articles/PMC5093112/ /pubmed/27857682 http://dx.doi.org/10.3389/fncel.2016.00257 Text en Copyright © 2016 Cavaliere, Aiello, Di Perri, Amico, Martial, Thibaut, Laureys and Soddu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Cavaliere, Carlo
Aiello, Marco
Di Perri, Carol
Amico, Enrico
Martial, Charlotte
Thibaut, Aurore
Laureys, Steven
Soddu, Andrea
Functional Connectivity Substrates for tDCS Response in Minimally Conscious State Patients
title Functional Connectivity Substrates for tDCS Response in Minimally Conscious State Patients
title_full Functional Connectivity Substrates for tDCS Response in Minimally Conscious State Patients
title_fullStr Functional Connectivity Substrates for tDCS Response in Minimally Conscious State Patients
title_full_unstemmed Functional Connectivity Substrates for tDCS Response in Minimally Conscious State Patients
title_short Functional Connectivity Substrates for tDCS Response in Minimally Conscious State Patients
title_sort functional connectivity substrates for tdcs response in minimally conscious state patients
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093112/
https://www.ncbi.nlm.nih.gov/pubmed/27857682
http://dx.doi.org/10.3389/fncel.2016.00257
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