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Functional Connectivity Substrates for tDCS Response in Minimally Conscious State Patients
Transcranial direct current stimulation (tDCS) is a non-invasive technique recently employed in disorders of consciousness, and determining a transitory recovery of signs of consciousness in almost half of minimally conscious state (MCS) patients. Although the rising evidences about its possible rol...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093112/ https://www.ncbi.nlm.nih.gov/pubmed/27857682 http://dx.doi.org/10.3389/fncel.2016.00257 |
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author | Cavaliere, Carlo Aiello, Marco Di Perri, Carol Amico, Enrico Martial, Charlotte Thibaut, Aurore Laureys, Steven Soddu, Andrea |
author_facet | Cavaliere, Carlo Aiello, Marco Di Perri, Carol Amico, Enrico Martial, Charlotte Thibaut, Aurore Laureys, Steven Soddu, Andrea |
author_sort | Cavaliere, Carlo |
collection | PubMed |
description | Transcranial direct current stimulation (tDCS) is a non-invasive technique recently employed in disorders of consciousness, and determining a transitory recovery of signs of consciousness in almost half of minimally conscious state (MCS) patients. Although the rising evidences about its possible role in the treatment of many neurological and psychiatric conditions exist, no evidences exist about brain functional connectivity substrates underlying tDCS response. We retrospectively evaluated resting state functional Magnetic Resonance Imaging (fMRI) of 16 sub-acute and chronic MCS patients (6 tDCS responders) who successively received a single left dorsolateral prefrontal cortex (DLPFC) tDCS in a double-blind randomized cross-over trial. A seed-based approach for regions of left extrinsic control network (ECN) and default-mode network (DMN) was performed. tDCS responders showed an increased left intra-network connectivity for regions co-activated with left DLPFC, and significantly with left inferior frontal gyrus. Non-responders (NR) MCS patients showed an increased connectivity between left DLPFC and midline cortical structures, including anterior cingulate cortex and precuneus. Our findings suggest that a prior high connectivity with regions belonging to ECN can facilitate transitory recovery of consciousness in a subgroup of MCS patients that underwent tDCS treatment. Therefore, resting state-fMRI could be very valuable in detecting the neuronal conditions necessary for tDCS to improve behavior in MCS. |
format | Online Article Text |
id | pubmed-5093112 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-50931122016-11-17 Functional Connectivity Substrates for tDCS Response in Minimally Conscious State Patients Cavaliere, Carlo Aiello, Marco Di Perri, Carol Amico, Enrico Martial, Charlotte Thibaut, Aurore Laureys, Steven Soddu, Andrea Front Cell Neurosci Neuroscience Transcranial direct current stimulation (tDCS) is a non-invasive technique recently employed in disorders of consciousness, and determining a transitory recovery of signs of consciousness in almost half of minimally conscious state (MCS) patients. Although the rising evidences about its possible role in the treatment of many neurological and psychiatric conditions exist, no evidences exist about brain functional connectivity substrates underlying tDCS response. We retrospectively evaluated resting state functional Magnetic Resonance Imaging (fMRI) of 16 sub-acute and chronic MCS patients (6 tDCS responders) who successively received a single left dorsolateral prefrontal cortex (DLPFC) tDCS in a double-blind randomized cross-over trial. A seed-based approach for regions of left extrinsic control network (ECN) and default-mode network (DMN) was performed. tDCS responders showed an increased left intra-network connectivity for regions co-activated with left DLPFC, and significantly with left inferior frontal gyrus. Non-responders (NR) MCS patients showed an increased connectivity between left DLPFC and midline cortical structures, including anterior cingulate cortex and precuneus. Our findings suggest that a prior high connectivity with regions belonging to ECN can facilitate transitory recovery of consciousness in a subgroup of MCS patients that underwent tDCS treatment. Therefore, resting state-fMRI could be very valuable in detecting the neuronal conditions necessary for tDCS to improve behavior in MCS. Frontiers Media S.A. 2016-11-03 /pmc/articles/PMC5093112/ /pubmed/27857682 http://dx.doi.org/10.3389/fncel.2016.00257 Text en Copyright © 2016 Cavaliere, Aiello, Di Perri, Amico, Martial, Thibaut, Laureys and Soddu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Cavaliere, Carlo Aiello, Marco Di Perri, Carol Amico, Enrico Martial, Charlotte Thibaut, Aurore Laureys, Steven Soddu, Andrea Functional Connectivity Substrates for tDCS Response in Minimally Conscious State Patients |
title | Functional Connectivity Substrates for tDCS Response in Minimally Conscious State Patients |
title_full | Functional Connectivity Substrates for tDCS Response in Minimally Conscious State Patients |
title_fullStr | Functional Connectivity Substrates for tDCS Response in Minimally Conscious State Patients |
title_full_unstemmed | Functional Connectivity Substrates for tDCS Response in Minimally Conscious State Patients |
title_short | Functional Connectivity Substrates for tDCS Response in Minimally Conscious State Patients |
title_sort | functional connectivity substrates for tdcs response in minimally conscious state patients |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093112/ https://www.ncbi.nlm.nih.gov/pubmed/27857682 http://dx.doi.org/10.3389/fncel.2016.00257 |
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