Cargando…

Efficacy of Scutellaria baicalensis for the Treatment of Hand, Foot, and Mouth Disease Associated with Encephalitis in Patients Infected with EV71: A Multicenter, Retrospective Analysis

This study aimed to evaluate the clinical efficacy and safety of using the traditional Chinese herbal medicine Scutellaria baicalensis for the treatment of severe HFMD in 725 patients aged >1 year in a multicenter, retrospective analysis. The patients were divided into the S. baicalensis and riba...

Descripción completa

Detalles Bibliográficos
Autores principales: Lin, Hailong, Zhou, Jian, Lin, Kaichun, Wang, Hongjiao, Liang, Zunhong, Ren, Xingshuai, Huang, Leting, Xia, Chan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093290/
https://www.ncbi.nlm.nih.gov/pubmed/27840828
http://dx.doi.org/10.1155/2016/5697571
_version_ 1782464890194100224
author Lin, Hailong
Zhou, Jian
Lin, Kaichun
Wang, Hongjiao
Liang, Zunhong
Ren, Xingshuai
Huang, Leting
Xia, Chan
author_facet Lin, Hailong
Zhou, Jian
Lin, Kaichun
Wang, Hongjiao
Liang, Zunhong
Ren, Xingshuai
Huang, Leting
Xia, Chan
author_sort Lin, Hailong
collection PubMed
description This study aimed to evaluate the clinical efficacy and safety of using the traditional Chinese herbal medicine Scutellaria baicalensis for the treatment of severe HFMD in 725 patients aged >1 year in a multicenter, retrospective analysis. The patients were divided into the S. baicalensis and ribavirin groups, and the temperatures, presence or absence of skin rashes and oral lesions, nervous system (NS) involvement, and viral loads of the patients, as well as the safety of the treatments, were evaluated. The median duration of fever, median time to NS involvement, and the number of patients with oral ulcers and/or vesicles, as well as skin rashes, were decreased in the S. baicalensis group compared with the ribavirin group. In addition, the EV71 viral loads were decreased in the S. baicalensis group, suggesting that S. baicalensis exerted more potent antiviral effects compared with ribavirin. The present study demonstrated that S. baicalensis was suitable for the treatment of severe HFMD in patients aged >1 year, since it was shown to rapidly relieve fever, attenuate oral lesions and rashes, and improve NS involvement. Furthermore, it was demonstrated to be relatively safe for topical application.
format Online
Article
Text
id pubmed-5093290
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-50932902016-11-13 Efficacy of Scutellaria baicalensis for the Treatment of Hand, Foot, and Mouth Disease Associated with Encephalitis in Patients Infected with EV71: A Multicenter, Retrospective Analysis Lin, Hailong Zhou, Jian Lin, Kaichun Wang, Hongjiao Liang, Zunhong Ren, Xingshuai Huang, Leting Xia, Chan Biomed Res Int Clinical Study This study aimed to evaluate the clinical efficacy and safety of using the traditional Chinese herbal medicine Scutellaria baicalensis for the treatment of severe HFMD in 725 patients aged >1 year in a multicenter, retrospective analysis. The patients were divided into the S. baicalensis and ribavirin groups, and the temperatures, presence or absence of skin rashes and oral lesions, nervous system (NS) involvement, and viral loads of the patients, as well as the safety of the treatments, were evaluated. The median duration of fever, median time to NS involvement, and the number of patients with oral ulcers and/or vesicles, as well as skin rashes, were decreased in the S. baicalensis group compared with the ribavirin group. In addition, the EV71 viral loads were decreased in the S. baicalensis group, suggesting that S. baicalensis exerted more potent antiviral effects compared with ribavirin. The present study demonstrated that S. baicalensis was suitable for the treatment of severe HFMD in patients aged >1 year, since it was shown to rapidly relieve fever, attenuate oral lesions and rashes, and improve NS involvement. Furthermore, it was demonstrated to be relatively safe for topical application. Hindawi Publishing Corporation 2016 2016-10-20 /pmc/articles/PMC5093290/ /pubmed/27840828 http://dx.doi.org/10.1155/2016/5697571 Text en Copyright © 2016 Hailong Lin et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Lin, Hailong
Zhou, Jian
Lin, Kaichun
Wang, Hongjiao
Liang, Zunhong
Ren, Xingshuai
Huang, Leting
Xia, Chan
Efficacy of Scutellaria baicalensis for the Treatment of Hand, Foot, and Mouth Disease Associated with Encephalitis in Patients Infected with EV71: A Multicenter, Retrospective Analysis
title Efficacy of Scutellaria baicalensis for the Treatment of Hand, Foot, and Mouth Disease Associated with Encephalitis in Patients Infected with EV71: A Multicenter, Retrospective Analysis
title_full Efficacy of Scutellaria baicalensis for the Treatment of Hand, Foot, and Mouth Disease Associated with Encephalitis in Patients Infected with EV71: A Multicenter, Retrospective Analysis
title_fullStr Efficacy of Scutellaria baicalensis for the Treatment of Hand, Foot, and Mouth Disease Associated with Encephalitis in Patients Infected with EV71: A Multicenter, Retrospective Analysis
title_full_unstemmed Efficacy of Scutellaria baicalensis for the Treatment of Hand, Foot, and Mouth Disease Associated with Encephalitis in Patients Infected with EV71: A Multicenter, Retrospective Analysis
title_short Efficacy of Scutellaria baicalensis for the Treatment of Hand, Foot, and Mouth Disease Associated with Encephalitis in Patients Infected with EV71: A Multicenter, Retrospective Analysis
title_sort efficacy of scutellaria baicalensis for the treatment of hand, foot, and mouth disease associated with encephalitis in patients infected with ev71: a multicenter, retrospective analysis
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093290/
https://www.ncbi.nlm.nih.gov/pubmed/27840828
http://dx.doi.org/10.1155/2016/5697571
work_keys_str_mv AT linhailong efficacyofscutellariabaicalensisforthetreatmentofhandfootandmouthdiseaseassociatedwithencephalitisinpatientsinfectedwithev71amulticenterretrospectiveanalysis
AT zhoujian efficacyofscutellariabaicalensisforthetreatmentofhandfootandmouthdiseaseassociatedwithencephalitisinpatientsinfectedwithev71amulticenterretrospectiveanalysis
AT linkaichun efficacyofscutellariabaicalensisforthetreatmentofhandfootandmouthdiseaseassociatedwithencephalitisinpatientsinfectedwithev71amulticenterretrospectiveanalysis
AT wanghongjiao efficacyofscutellariabaicalensisforthetreatmentofhandfootandmouthdiseaseassociatedwithencephalitisinpatientsinfectedwithev71amulticenterretrospectiveanalysis
AT liangzunhong efficacyofscutellariabaicalensisforthetreatmentofhandfootandmouthdiseaseassociatedwithencephalitisinpatientsinfectedwithev71amulticenterretrospectiveanalysis
AT renxingshuai efficacyofscutellariabaicalensisforthetreatmentofhandfootandmouthdiseaseassociatedwithencephalitisinpatientsinfectedwithev71amulticenterretrospectiveanalysis
AT huangleting efficacyofscutellariabaicalensisforthetreatmentofhandfootandmouthdiseaseassociatedwithencephalitisinpatientsinfectedwithev71amulticenterretrospectiveanalysis
AT xiachan efficacyofscutellariabaicalensisforthetreatmentofhandfootandmouthdiseaseassociatedwithencephalitisinpatientsinfectedwithev71amulticenterretrospectiveanalysis