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The effect of ginger supplementation on serum C-reactive protein, lipid profile and glycaemia: a systematic review and meta-analysis
AIM: To undertake a systematic review and meta-analysis of prospective studies to determine the effect of ginger supplementation on serum C-reactive protein (CRP), lipid profile, and glycaemia. METHOD: PubMed-MEDLINE, Web of Science, Cochrane Database, and Google Scholar databases were searched (up...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Co-Action Publishing
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093315/ https://www.ncbi.nlm.nih.gov/pubmed/27806832 http://dx.doi.org/10.3402/fnr.v60.32613 |
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author | Mazidi, Mohsen Gao, Hong-Kai Rezaie, Peyman Ferns, Gordon A. |
author_facet | Mazidi, Mohsen Gao, Hong-Kai Rezaie, Peyman Ferns, Gordon A. |
author_sort | Mazidi, Mohsen |
collection | PubMed |
description | AIM: To undertake a systematic review and meta-analysis of prospective studies to determine the effect of ginger supplementation on serum C-reactive protein (CRP), lipid profile, and glycaemia. METHOD: PubMed-MEDLINE, Web of Science, Cochrane Database, and Google Scholar databases were searched (up until July 2016) to identify prospective studies evaluating the impact of ginger supplementation on serum CRP. Random-effects model meta-analysis was used for quantitative data synthesis. Sensitivity analysis was conducted using the leave-one-out method. Heterogeneity was quantitatively assessed using the I(2) index. Systematic review registration: CRD42016035973. RESULTS: From a total of 265 entries identified via searches, 9 studies were included in the final selection. The meta-analysis indicated a significant reduction in serum CRP concentrations following ginger supplementation [weighted mean difference (WMD)−0.84 mg/L (95% CI −1.38 to −0.31, I(2) 56.3%)]. The WMD for fasting blood glucose and HbA1c was −1.35 mg/dl (95% CI −2.04 to −0.58, I(2) 12.1%) and −1.01 (95% CI −1.28 to −0.72, I(2) 9.4%), respectively. Moreover, high-density lipoprotein and triglyceride significantly improved after ginger administration [1.16 mg/dl (95% CI 0.52 to 1.08, I(2) 12.3%) and −1.63 mg/dl (95% CI −3.10 to −0.17, I(2) 8.1%), respectively]. These findings were robust in sensitivity analyses. Random-effects meta-regression revealed that changes in serum CRP levels were independent of the dosage of ginger supplementation (slope −0.20; 95% CI −0.95 to 0.55; p=0.60). CONCLUSIONS: This meta-analysis suggests that ginger supplementation significantly reduces serum CRP and improves glycaemia indexes and lipid profile. Randomized control trials with larger sample size and with a longer-term follow-up period should be considered for future investigations. |
format | Online Article Text |
id | pubmed-5093315 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Co-Action Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-50933152016-11-17 The effect of ginger supplementation on serum C-reactive protein, lipid profile and glycaemia: a systematic review and meta-analysis Mazidi, Mohsen Gao, Hong-Kai Rezaie, Peyman Ferns, Gordon A. Food Nutr Res Meta-Analyses AIM: To undertake a systematic review and meta-analysis of prospective studies to determine the effect of ginger supplementation on serum C-reactive protein (CRP), lipid profile, and glycaemia. METHOD: PubMed-MEDLINE, Web of Science, Cochrane Database, and Google Scholar databases were searched (up until July 2016) to identify prospective studies evaluating the impact of ginger supplementation on serum CRP. Random-effects model meta-analysis was used for quantitative data synthesis. Sensitivity analysis was conducted using the leave-one-out method. Heterogeneity was quantitatively assessed using the I(2) index. Systematic review registration: CRD42016035973. RESULTS: From a total of 265 entries identified via searches, 9 studies were included in the final selection. The meta-analysis indicated a significant reduction in serum CRP concentrations following ginger supplementation [weighted mean difference (WMD)−0.84 mg/L (95% CI −1.38 to −0.31, I(2) 56.3%)]. The WMD for fasting blood glucose and HbA1c was −1.35 mg/dl (95% CI −2.04 to −0.58, I(2) 12.1%) and −1.01 (95% CI −1.28 to −0.72, I(2) 9.4%), respectively. Moreover, high-density lipoprotein and triglyceride significantly improved after ginger administration [1.16 mg/dl (95% CI 0.52 to 1.08, I(2) 12.3%) and −1.63 mg/dl (95% CI −3.10 to −0.17, I(2) 8.1%), respectively]. These findings were robust in sensitivity analyses. Random-effects meta-regression revealed that changes in serum CRP levels were independent of the dosage of ginger supplementation (slope −0.20; 95% CI −0.95 to 0.55; p=0.60). CONCLUSIONS: This meta-analysis suggests that ginger supplementation significantly reduces serum CRP and improves glycaemia indexes and lipid profile. Randomized control trials with larger sample size and with a longer-term follow-up period should be considered for future investigations. Co-Action Publishing 2016-11-01 /pmc/articles/PMC5093315/ /pubmed/27806832 http://dx.doi.org/10.3402/fnr.v60.32613 Text en © 2016 Mohsen Mazidi et al. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for any purpose, even commercially, provided the original work is properly cited and states its license. |
spellingShingle | Meta-Analyses Mazidi, Mohsen Gao, Hong-Kai Rezaie, Peyman Ferns, Gordon A. The effect of ginger supplementation on serum C-reactive protein, lipid profile and glycaemia: a systematic review and meta-analysis |
title | The effect of ginger supplementation on serum C-reactive protein, lipid profile and glycaemia: a systematic review and meta-analysis |
title_full | The effect of ginger supplementation on serum C-reactive protein, lipid profile and glycaemia: a systematic review and meta-analysis |
title_fullStr | The effect of ginger supplementation on serum C-reactive protein, lipid profile and glycaemia: a systematic review and meta-analysis |
title_full_unstemmed | The effect of ginger supplementation on serum C-reactive protein, lipid profile and glycaemia: a systematic review and meta-analysis |
title_short | The effect of ginger supplementation on serum C-reactive protein, lipid profile and glycaemia: a systematic review and meta-analysis |
title_sort | effect of ginger supplementation on serum c-reactive protein, lipid profile and glycaemia: a systematic review and meta-analysis |
topic | Meta-Analyses |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093315/ https://www.ncbi.nlm.nih.gov/pubmed/27806832 http://dx.doi.org/10.3402/fnr.v60.32613 |
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