PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation

Sepsis, severe sepsis and septic shock are the main cause of mortality in non-cardiac intensive care units. Immunometabolism has been linked to sepsis; however, the precise mechanism by which metabolic reprogramming regulates the inflammatory response is unclear. Here we show that aerobic glycolysis...

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Detalles Bibliográficos
Autores principales: Xie, Min, Yu, Yan, Kang, Rui, Zhu, Shan, Yang, Liangchun, Zeng, Ling, Sun, Xiaofang, Yang, Minghua, Billiar, Timothy R., Wang, Haichao, Cao, Lizhi, Jiang, Jianxin, Tang, Daolin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093342/
https://www.ncbi.nlm.nih.gov/pubmed/27779186
http://dx.doi.org/10.1038/ncomms13280

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