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Epac1 interacts with importin β1 and controls neurite outgrowth independently of cAMP and Rap1

Exchange protein directly activated by cAMP-1 (Epac1) is a cAMP sensor that regulates multiple cellular functions including cellular migration, proliferation and differentiation. Classically, Epac1 is thought to exert its effects through binding of cAMP leading to a conformational change in Epac1 an...

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Detalles Bibliográficos
Autores principales:	Baameur, Faiza, Singhmar, Pooja, Zhou, Yong, Hancock, John F., Cheng, Xiaodong, Heijnen, Cobi J., Kavelaars, Annemieke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093460/ https://www.ncbi.nlm.nih.gov/pubmed/27808165 http://dx.doi.org/10.1038/srep36370

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