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T cells in multiple myeloma display features of exhaustion and senescence at the tumor site

BACKGROUND: Multiple myeloma is an incurable plasma cell malignancy that is mostly restricted to the bone marrow. Cancer-induced dysfunction of cytotoxic T cells at the tumor site may be responsible for immune evasion and therapeutical failure of immunotherapies. Therefore, enhanced knowledge about...

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Detalles Bibliográficos
Autores principales:	Zelle-Rieser, Claudia, Thangavadivel, Shanmugapriya, Biedermann, Rainer, Brunner, Andrea, Stoitzner, Patrizia, Willenbacher, Ella, Greil, Richard, Jöhrer, Karin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093947/ https://www.ncbi.nlm.nih.gov/pubmed/27809856 http://dx.doi.org/10.1186/s13045-016-0345-3

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