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Impact of glycemic control with sitagliptin on the 2-year progression of arterial stiffness: a sub-analysis of the PROLOGUE study

BACKGROUND: No conclusive evidence has been obtained yet on the significance of the effects of dipeptidyl peptidase-4 (DPP-4 inhibitor) treatment on the arterial stiffness in clinical settings. In addition, the effects of good glycemic control on the arterial stiffness have also not been clarified y...

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Autores principales: Tomiyama, Hirofumi, Miwa, Takashi, Kan, Kenshi, Matsuhisa, Munehide, Kamiya, Haruo, Nanasato, Mamoru, Kitano, Tomoki, Sano, Hiroaki, Ohno, Jun, Iida, Masato, Sata, Masataka, Yamada, Hirotsugu, Maemura, Koji, Tanaka, Atsushi, Murohara, Toyoaki, Node, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094002/
https://www.ncbi.nlm.nih.gov/pubmed/27809848
http://dx.doi.org/10.1186/s12933-016-0472-8
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author Tomiyama, Hirofumi
Miwa, Takashi
Kan, Kenshi
Matsuhisa, Munehide
Kamiya, Haruo
Nanasato, Mamoru
Kitano, Tomoki
Sano, Hiroaki
Ohno, Jun
Iida, Masato
Sata, Masataka
Yamada, Hirotsugu
Maemura, Koji
Tanaka, Atsushi
Murohara, Toyoaki
Node, Koichi
author_facet Tomiyama, Hirofumi
Miwa, Takashi
Kan, Kenshi
Matsuhisa, Munehide
Kamiya, Haruo
Nanasato, Mamoru
Kitano, Tomoki
Sano, Hiroaki
Ohno, Jun
Iida, Masato
Sata, Masataka
Yamada, Hirotsugu
Maemura, Koji
Tanaka, Atsushi
Murohara, Toyoaki
Node, Koichi
author_sort Tomiyama, Hirofumi
collection PubMed
description BACKGROUND: No conclusive evidence has been obtained yet on the significance of the effects of dipeptidyl peptidase-4 (DPP-4 inhibitor) treatment on the arterial stiffness in clinical settings. In addition, the effects of good glycemic control on the arterial stiffness have also not been clarified yet. As a sub-analysis of the PROLOGUE study, we examined the effect of a DPP-4 inhibitor (sitagliptin) on the 2-year progression of the arterial stiffness and also to determine the effect of good glycemic control on the rate of progression of the arterial stiffness. METHODS: In the PROLOGUE study, the study participants were either allocated to add-on sitagliptin treatment or to continued treatment with conventional anti-diabetic agents. Among the 463 participants of the PROLOGUE study, we succeeded in measuring the brachial-ankle pulse wave velocity (baPWV) at least two times during the 2-year study period in 96 subjects. RESULTS: The changes in the baPWV during the study period were similar between the both groups (i.e., with/without staglipitin), overall. On the other hand, when the study subjects were divided into two groups according to the glycemic control status during the study period {good glycemic control group (GC) = hemoglobin (Hb)A1c <7.0 at both 12 and 24 months after the treatment randomization; poor glycemic control group (PC) = HbA1c ≥7.0 at either 12 months, 24 months, or both}, the 2-year increase of the baPWV was marginally significantly larger in the PC group (144 ± 235 cm/s) as compared to that the GC group (−10 ± 282 cm/s) (p = 0.036). CONCLUSION: While the present study could not confirm the beneficial effect of sitagliptin per se on the arterial stiffness, the results suggested that good glycemic control appears to be beneficial for delaying the annual progression of the arterial stiffness. Trial registration University Hospital Medical Information Network Clinical Trials Registry UMIN000004490
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spelling pubmed-50940022016-11-07 Impact of glycemic control with sitagliptin on the 2-year progression of arterial stiffness: a sub-analysis of the PROLOGUE study Tomiyama, Hirofumi Miwa, Takashi Kan, Kenshi Matsuhisa, Munehide Kamiya, Haruo Nanasato, Mamoru Kitano, Tomoki Sano, Hiroaki Ohno, Jun Iida, Masato Sata, Masataka Yamada, Hirotsugu Maemura, Koji Tanaka, Atsushi Murohara, Toyoaki Node, Koichi Cardiovasc Diabetol Original Investigation BACKGROUND: No conclusive evidence has been obtained yet on the significance of the effects of dipeptidyl peptidase-4 (DPP-4 inhibitor) treatment on the arterial stiffness in clinical settings. In addition, the effects of good glycemic control on the arterial stiffness have also not been clarified yet. As a sub-analysis of the PROLOGUE study, we examined the effect of a DPP-4 inhibitor (sitagliptin) on the 2-year progression of the arterial stiffness and also to determine the effect of good glycemic control on the rate of progression of the arterial stiffness. METHODS: In the PROLOGUE study, the study participants were either allocated to add-on sitagliptin treatment or to continued treatment with conventional anti-diabetic agents. Among the 463 participants of the PROLOGUE study, we succeeded in measuring the brachial-ankle pulse wave velocity (baPWV) at least two times during the 2-year study period in 96 subjects. RESULTS: The changes in the baPWV during the study period were similar between the both groups (i.e., with/without staglipitin), overall. On the other hand, when the study subjects were divided into two groups according to the glycemic control status during the study period {good glycemic control group (GC) = hemoglobin (Hb)A1c <7.0 at both 12 and 24 months after the treatment randomization; poor glycemic control group (PC) = HbA1c ≥7.0 at either 12 months, 24 months, or both}, the 2-year increase of the baPWV was marginally significantly larger in the PC group (144 ± 235 cm/s) as compared to that the GC group (−10 ± 282 cm/s) (p = 0.036). CONCLUSION: While the present study could not confirm the beneficial effect of sitagliptin per se on the arterial stiffness, the results suggested that good glycemic control appears to be beneficial for delaying the annual progression of the arterial stiffness. Trial registration University Hospital Medical Information Network Clinical Trials Registry UMIN000004490 BioMed Central 2016-11-03 /pmc/articles/PMC5094002/ /pubmed/27809848 http://dx.doi.org/10.1186/s12933-016-0472-8 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Original Investigation
Tomiyama, Hirofumi
Miwa, Takashi
Kan, Kenshi
Matsuhisa, Munehide
Kamiya, Haruo
Nanasato, Mamoru
Kitano, Tomoki
Sano, Hiroaki
Ohno, Jun
Iida, Masato
Sata, Masataka
Yamada, Hirotsugu
Maemura, Koji
Tanaka, Atsushi
Murohara, Toyoaki
Node, Koichi
Impact of glycemic control with sitagliptin on the 2-year progression of arterial stiffness: a sub-analysis of the PROLOGUE study
title Impact of glycemic control with sitagliptin on the 2-year progression of arterial stiffness: a sub-analysis of the PROLOGUE study
title_full Impact of glycemic control with sitagliptin on the 2-year progression of arterial stiffness: a sub-analysis of the PROLOGUE study
title_fullStr Impact of glycemic control with sitagliptin on the 2-year progression of arterial stiffness: a sub-analysis of the PROLOGUE study
title_full_unstemmed Impact of glycemic control with sitagliptin on the 2-year progression of arterial stiffness: a sub-analysis of the PROLOGUE study
title_short Impact of glycemic control with sitagliptin on the 2-year progression of arterial stiffness: a sub-analysis of the PROLOGUE study
title_sort impact of glycemic control with sitagliptin on the 2-year progression of arterial stiffness: a sub-analysis of the prologue study
topic Original Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094002/
https://www.ncbi.nlm.nih.gov/pubmed/27809848
http://dx.doi.org/10.1186/s12933-016-0472-8
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