Efficacy of naloxone in reducing postictal central respiratory dysfunction in patients with epilepsy: study protocol for a double-blind, randomized, placebo-controlled trial

BACKGROUND: Generalized tonic-clonic seizures (GTCSs) are the main risk factor for sudden unexpected death in epilepsy (SUDEP). Experimental and clinical data strongly suggest that the majority of SUDEP results from a postictal respiratory dysfunction progressing to terminal apnea. Postictal apnea c...

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Detalles Bibliográficos
Autores principales: Rheims, Sylvain, Valton, Luc, Michel, Véronique, Maillard, Louis, Navarro, Vincent, Convers, Philippe, Bartolomei, Fabrice, Biraben, Arnaud, Crespel, Arielle, Derambure, Philippe, de Toffol, Bertrand, Hirsch, Edouard, Kahane, Philippe, Martin, Martine Lemesle, Tourniaire, Didier, Boulogne, Sébastien, Mercier, Catherine, Roy, Pascal, Ryvlin, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094038/
https://www.ncbi.nlm.nih.gov/pubmed/27809868
http://dx.doi.org/10.1186/s13063-016-1653-1

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